Literature DB >> 6510632

Carcinogenicity in rats of ptaquiloside isolated from bracken.

I Hirono, S Aiso, T Yamaji, H Mori, K Yamada, H Niwa, M Ojika, K Wakamatsu, H Kigoshi, K Niiyama.   

Abstract

The nature of the carcinogen present in bracken fern has not yet been elucidated. Very recently, we succeeded in isolating ptaquiloside, a novel norsesquiterpene glucoside of the illudane type, from bracken. Ptaquiloside was shown to be a carcinogenic principle of bracken fern. It induces mammary cancer and multiple ileal tumors in high incidences when given orally to female Sprague-Dawley rats.

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Year:  1984        PMID: 6510632

Source DB:  PubMed          Journal:  Gan        ISSN: 0016-450X


  3 in total

1.  Ontogenic variation of biologically active metabolites ofPteridium aquilinum (L. Kuhn) pterosins A and B, and ptaquiloside in a bracken population of the tropical andes.

Authors:  M E Alonso-Amelot; M Pérez-Mena; M P Calcagno; R Jaimes-Espinoza; U Castillo
Journal:  J Chem Ecol       Date:  1992-08       Impact factor: 2.626

2.  Bracken fern-induced bladder tumors in guinea pigs. A model for human neoplasia.

Authors:  P P Bringuier; E Piaton; N Berger; F Debruyne; P Perrin; J Schalken; M Devonec
Journal:  Am J Pathol       Date:  1995-09       Impact factor: 4.307

Review 3.  Edible plants containing naturally occurring carcinogens in Japan.

Authors:  I Hirono
Journal:  Jpn J Cancer Res       Date:  1993-10
  3 in total

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