Literature DB >> 6510498

Low-molecular-weight enzyme inhibitors suppress the development of experimental allergic encephalomyelitis.

T Aoyagi, T Wada, M Nagai, H Sakaguchi, T Osanai, Y Nagai, H Umezawa.   

Abstract

We tested the activity of low-molecular-weight enzyme inhibitors with immunomodifying actions on the suppression of experimental allergic encephalomyelitis (EAE). Of the agents tested the inhibitors of alkaline phosphatase, aminopeptidase B and esterase gave significant protection against the clinical expression of EAE in guinea pigs.

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Year:  1984        PMID： 6510498     DOI： 10.1007/bf01951914

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  11 in total

1.  Forphenicine, and inhibitor of alkaline phosphatase produced by actinomycetes.

Authors:  T Aoyagi; T Yamamoto; K Kojiri; F Kojima; M Hamada; T Takeuchi; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1978-03       Impact factor: 2.649

2.  Kinetics and inhibition of alkaline phosphatases from canine tissues.

Authors:  H Van Belle
Journal:  Biochim Biophys Acta       Date:  1972-11-10

3.  Proteinase inhibitors suppress the development of experimental allergic encephalomyelitis.

Authors:  C F Brosnan; W Cammer; W T Norton; B R Bloom
Journal:  Nature       Date:  1980-05-22       Impact factor: 49.962

4.  Esterastin, an inhibitor of esterase, produced by actinomycetes.

Authors:  H Umezawa; T Aoyagi; T Hazato; K Uotani; F Kojima; M Hamada; T Takeuchi
Journal:  J Antibiot (Tokyo)       Date:  1978-06       Impact factor: 2.649

5.  Arphamenines A and B, new inhibitors of aminopeptidase B, produced by bacteria.

Authors:  H Umezawa; T Aoyagi; S Ohuchi; A Okuyama; H Suda; T Takita; M Hamada; T Takeuchi
Journal:  J Antibiot (Tokyo)       Date:  1983-11       Impact factor: 2.649

Review 6.  Immunotherapy: the old and the new.

Authors:  R K Oldham; R V Smalley
Journal:  J Biol Response Mod       Date:  1983

7.  Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes.

Authors:  T Aoyagi; H Tobe; F Kojima; M Hamada; T Takeuchi; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1978-06       Impact factor: 2.649

8.  Ebelactone, an inhibitor of esterase, produced by actinomycetes.

Authors:  H Umezawa; T Aoyagi; K Uotani; M Hamada; T Takeuchi; S Takahashi
Journal:  J Antibiot (Tokyo)       Date:  1980-12       Impact factor: 2.649

9.  Enhancement of encephalitogenic activity by the formation of myelin basic protein-brain acidic protein complex.

Authors:  T Yasuda; T Tsumita; Y Nagai
Journal:  Jpn J Exp Med       Date:  1975-10

10.  Systemic enzymatic changes in guinea pigs suffering from experimental allergic encephalomyelitis.

Authors:  T Aoyagi; T Wada; Y Ishikawa; F Kojima; M Nagai; T Osanai; Y Nagai; H Umezawa
Journal:  J Pharmacobiodyn       Date:  1983-12
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