Literature DB >> 6509437

The mouse ear edema: a quantitatively evaluable assay for tumor promoting compounds and for inhibitors of tumor promotion.

M Gschwendt, W Kittstein, G Fürstenberger, F Marks.   

Abstract

The induction of edema in the mouse ear has been established as a reliable in vivo assay for tumor promoting compounds and for inhibitors of tumor promotion. Apparently all skin tumor promoting compounds induce an edema, and all inhibitors of a tumor promoter-induced edema are most likely inhibitors of skin tumor promotion. No exception to this rule has been found as yet. Besides the application of this assay in the screening of compounds, the assay allows comparison of various compounds (e.g. complete and incomplete tumor promoters) with respect to their kinetics and dosage response in the induction of edema.

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Year:  1984        PMID： 6509437     DOI： 10.1016/s0304-3835(84)80043-9

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  10 in total

1.  Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor.

Authors:  H M Reichardt; J P Tuckermann; M Göttlicher; M Vujic; F Weih; P Angel; P Herrlich; G Schütz
Journal:  EMBO J       Date:  2001-12-17       Impact factor: 11.598

2.  Protein kinase C regulates urea permeability in the rat inner medullary collecting duct.

Authors:  Yanhua Wang; Janet D Klein; Carole M Liedtke; Jeff M Sands
Journal:  Am J Physiol Renal Physiol       Date:  2010-09-22

3.  Purified canola lutein selectively inhibits specific isoforms of mammalian DNA polymerases and reduces inflammatory response.

Authors:  Sho Horie; Chiaki Okuda; Takatoshi Yamashita; Kenichi Watanabe; Kouji Kuramochi; Masashi Hosokawa; Toshifumi Takeuchi; Makiko Kakuda; Kazuo Miyashita; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
Journal:  Lipids       Date:  2010-07-29       Impact factor: 1.880

4.  Characteristics and modulation of dithranol (anthralin)-induced skin irritation in the mouse ear model.

Authors:  M Viluksela
Journal:  Arch Dermatol Res       Date:  1991       Impact factor: 3.017

5.  Effects of antiinflammatory agents on edema and DNA synthesis induced by 12-O-tetradecanoylphorbol-13-acetate in the guinea pig.

Authors:  C Delescluse; P Vaigot; J Bailly; C N Hensby
Journal:  Agents Actions       Date:  1987-08

6.  Effects of intermediates between vitamins K(2) and K(3) on mammalian DNA polymerase inhibition and anti-inflammatory activity.

Authors:  Yoshiyuki Mizushina; Jun Maeda; Yasuhiro Irino; Masayuki Nishida; Shin Nishiumi; Yasuyuki Kondo; Kazuyuki Nishio; Kouji Kuramochi; Kazunori Tsubaki; Isoko Kuriyama; Takeshi Azuma; Hiromi Yoshida; Masaru Yoshida
Journal:  Int J Mol Sci       Date:  2011-02-10       Impact factor: 5.923

7.  The thyroid hormone receptors modulate the skin response to retinoids.

Authors:  Laura García-Serrano; María Ana Gomez-Ferrería; Constanza Contreras-Jurado; Carmen Segrelles; Jesus M Paramio; Ana Aranda
Journal:  PLoS One       Date:  2011-08-17       Impact factor: 3.240

8.  Inhibitory effects of glycyrrhetinic Acid on DNA polymerase and inflammatory activities.

Authors:  Tsukasa Ishida; Yoshiyuki Mizushina; Saori Yagi; Yasuhiro Irino; Shin Nishiumi; Ikuya Miki; Yasuyuki Kondo; Shigeto Mizuno; Hiromi Yoshida; Takeshi Azuma; Masaru Yoshida
Journal:  Evid Based Complement Alternat Med       Date:  2011-07-14       Impact factor: 2.629

9.  Ethanolic Extract of Origanum vulgare Suppresses Propionibacterium acnes-Induced Inflammatory Responses in Human Monocyte and Mouse Ear Edema Models.

Authors:  Lu-Te Chuang; Tsung-Hsien Tsai; Tsung-Jung Lien; Wen-Cheng Huang; Jun-Jen Liu; Hsiang Chang; Mei-Ling Chang; Po-Jung Tsai
Journal:  Molecules       Date:  2018-08-09       Impact factor: 4.411

10.  Practical Synthesis of Chalcone Derivatives and Their Biological Activities.

Authors:  Jae-Chul Jung; Yongnam Lee; Dongguk Min; Mankil Jung; Seikwan Oh
Journal:  Molecules       Date:  2017-11-01       Impact factor: 4.411
  10 in total

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