Literature DB >> 6509322

Hyperpolarizing action of baclofen on neurons in the rat substantia nigra slice.

R D Pinnock.   

Abstract

GABA, muscimol and L-baclofen inhibited zona compacta neurons in the rat substantia nigra slice, D-baclofen was inactive, L-baclofen produced a potent hyperpolarization of the membrane potential. The actions of muscimol but not GABA and L-baclofen were reversed by bicuculline. The actions of muscimol and baclofen are likely to be mediated by interactions with two different receptors.

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Year:  1984        PMID： 6509322     DOI： 10.1016/0006-8993(84)90129-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  11 in total

1.  Complete suppression of craving in alcohol-dependent individuals: is it possible?

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Journal:  CNS Drugs       Date:  2009       Impact factor: 5.749

2.  Cocaine effects in the ventral tegmental area: evidence for an indirect dopaminergic mechanism of action.

Authors:  M S Brodie; T V Dunwiddie
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-12       Impact factor: 3.000

3.  In vivo release of dopamine from rat striatum, substantia nigra and prefrontal cortex: differential modulation by baclofen.

Authors:  M Santiago; A Machado; J Cano
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

Review 4.  Baclofen reduces post-synaptic potentials of rat cortical neurones by an action other than its hyperpolarizing action.

Authors:  J R Howe; B Sutor; W Zieglgänsberger
Journal:  J Physiol       Date:  1987-03       Impact factor: 5.182

5.  Actions of the GABAB agonist, (-)-baclofen, on neurones in deep dorsal horn of the rat spinal cord in vitro.

Authors:  C A Allerton; P R Boden; R G Hill
Journal:  Br J Pharmacol       Date:  1989-01       Impact factor: 8.739

6.  A patch clamp study of gamma-aminobutyric acid (GABA)-induced macroscopic currents in rat melanotrophs in cell culture.

Authors:  S J Kehl; D Hughes; R N McBurney
Journal:  Br J Pharmacol       Date:  1987-11       Impact factor: 8.739

7.  GABAergic afferents activate both GABAA and GABAB receptors in mouse substantia nigra dopaminergic neurons in vivo.

Authors:  Elena Brazhnik; Fulva Shah; James M Tepper
Journal:  J Neurosci       Date:  2008-10-08       Impact factor: 6.167

8.  Potential interactions between GABAb and cholinergic systems: baclofen augments scopolamine-induced performance deficits in the eight-arm radial maze.

Authors:  E S Sidel; H A Tilson; R L McLamb; W A Wilson; H S Swartzwelder
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

9.  On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones.

Authors:  M G Lacey; N B Mercuri; R A North
Journal:  J Physiol       Date:  1988-07       Impact factor: 5.182

10.  Autoradiographic localization of gamma-aminobutyric acidA receptors within the ventral tegmental area.

Authors:  L Churchill; R P Dilts; P W Kalivas
Journal:  Neurochem Res       Date:  1992-01       Impact factor: 3.996
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