Literature DB >> 6509012

Purification and sequence of a presynaptic peptide toxin from Conus geographus venom.

B M Olivera, J M McIntosh, L J Cruz, F A Luque, W R Gray.   

Abstract

A novel toxin, omega-conotoxin (omega-CgTX), from the venom of the fish-eating marine mollusc Conus geographus has been purified and biochemically characterized. Recently, this omega-conotoxin has been shown to inhibit the voltage-activated entry of Ca2+, thus providing a potentially powerful probe for exploring the vertebrate presynaptic terminal [Kerr, L. M., & Yoshikami, D. (1984) Nature (London) 308, 282-284]. The toxin is a basic 27 amino acid peptide amide with three disulfide bridges. An unusual feature is a remarkable preponderance of hydroxylated amino acids. The sequence of omega-CgTx GVIA is Cys-Lys-Ser- Hyp-Gly5-Ser-Ser-Cys-Ser-Hyp10-Thr-Ser-Tyr-Asn-Cys15-C ys-Arg-Ser- Cys-Asn20-Hyp-Tyr-Thr-Lys-Arg25-Cys-Tyr-NH2.

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Year:  1984        PMID： 6509012     DOI： 10.1021/bi00317a001

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  84 in total

1.  An R-type Ca(2+) current in neurohypophysial terminals preferentially regulates oxytocin secretion.

Authors:  G Wang; G Dayanithi; R Newcomb; J R Lemos
Journal:  J Neurosci       Date:  1999-11-01       Impact factor: 6.167

2.  Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels.

Authors:  E Bourinet; S C Stotz; R L Spaetgens; G Dayanithi; J Lemos; J Nargeot; G W Zamponi
Journal:  Biophys J       Date:  2001-07       Impact factor: 4.033

3.  Ionic currents in cultured rat hypothalamic neurones.

Authors:  T H Müller; U Misgeld; D Swandulla
Journal:  J Physiol       Date:  1992-05       Impact factor: 5.182

4.  Molecular cloning of the alpha-1 subunit of an omega-conotoxin-sensitive calcium channel.

Authors:  S J Dubel; T V Starr; J Hell; M K Ahlijanian; J J Enyeart; W A Catterall; T P Snutch
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

Review 5.  Targeting voltage-gated calcium channels: developments in peptide and small-molecule inhibitors for the treatment of neuropathic pain.

Authors:  S Vink; P F Alewood
Journal:  Br J Pharmacol       Date:  2012-11       Impact factor: 8.739

6.  Site-specific effects of diselenide bridges on the oxidative folding of a cystine knot peptide, omega-selenoconotoxin GVIA.

Authors:  Konkallu Hanumae Gowd; Viktor Yarotskyy; Keith S Elmslie; Jack J Skalicky; Baldomero M Olivera; Grzegorz Bulaj
Journal:  Biochemistry       Date:  2010-03-30       Impact factor: 3.162

7.  SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons.

Authors:  Lei Wen; Sheng Yang; Haifa Qiao; Zhenwei Liu; Wenxia Zhou; Yongxiang Zhang; Peitang Huang
Journal:  Br J Pharmacol       Date:  2005-07       Impact factor: 8.739

8.  Effects of Ca2+ channel blockers on transmitter release and presynaptic currents at the frog neuromuscular junction.

Authors:  E Katz; P A Ferro; B D Cherksey; M Sugimori; R Llinás; O D Uchitel
Journal:  J Physiol       Date:  1995-08-01       Impact factor: 5.182

9.  Characteristics of omega-conotoxin GVI A and MVIIC binding to Cav 2.1 and Cav 2.2 channels captured by anti-Ca2+ channel peptide antibodies.

Authors:  Seiji Ichida; Junichi Abe; Kuniyo Komoike; Takashi Imanishi; Tetsuyuki Wada; Takashi Masuko; Takeshi Minami
Journal:  Neurochem Res       Date:  2005-04       Impact factor: 3.996

10.  Specific bindings of [3H](+)PN200-110 and [125I]omega-conotoxin to crude membranes from differentiated NG108-15 cells.

Authors:  S Ichida; T Wada; S Nakazaki; N Matsuda; H Kishino; T Akimoto
Journal:  Neurochem Res       Date:  1993-05       Impact factor: 3.996
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