Literature DB >> 6508714

Tissue osmolality, metabolic response, and reperfusion in myocardial ischemia.

W J Krieger, H F ter Welle, J W Fiolet, M J Janse.   

Abstract

We studied the effect of tonicity of the perfusate during reperfusion after global ischemia, in both the rat and the porcine heart. After 50 min, tissue osmolality increased by about 40 mOsm/kg. Normotonic as well as hypertonic reperfusion resulted in limited areas of "no-reflow". Metabolic restoration after reperfusion was not dependent on the tonicity of the perfusate, nor was recovery of contractility. Hypertonic reperfusion induced a higher coronary flow rate. In porcine hearts, scatter of metabolic data indicated inhomogeneity of reperfused tissue. The results differ substantially from data obtained after reperfusion of regionally ischemic hearts. Reasons for these differences are discussed.

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Year:  1984        PMID： 6508714     DOI： 10.1007/bf01910485

Source DB:  PubMed          Journal:  Basic Res Cardiol        ISSN： 0300-8428            Impact factor:   17.165


  19 in total

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Authors:  E J CONWAY; H GEOGHEGAN; J I MCCORMACK
Journal:  J Physiol       Date:  1955-11-28       Impact factor: 5.182

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Journal:  Circulation       Date:  1977-08       Impact factor: 29.690

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Journal:  Circ Res       Date:  1977-08       Impact factor: 17.367

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Authors:  H Stam; J W De Jong
Journal:  J Mol Cell Cardiol       Date:  1977-08       Impact factor: 5.000

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Authors:  K Schwartz; P Rey; M de Mendonca
Journal:  J Mol Cell Cardiol       Date:  1973-06       Impact factor: 5.000

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Authors:  F J Haddy; J B Scott
Journal:  Physiol Rev       Date:  1968-10       Impact factor: 37.312

7.  Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs.

Authors:  G R Heyndrickx; R W Millard; R J McRitchie; P R Maroko; S F Vatner
Journal:  J Clin Invest       Date:  1975-10       Impact factor: 14.808

8.  The relationship of ischemic contracture of vascular reperfusion in the isolated rat heart.

Authors:  S M Humphrey; J B Gavin; P B Herdson
Journal:  J Mol Cell Cardiol       Date:  1980-12       Impact factor: 5.000

9.  The influence of reperfusin on infarct size after experimental coronary artery occlusion.

Authors:  M Hofmann; M Hofmann; K Genth; W Schaper
Journal:  Basic Res Cardiol       Date:  1980 Jul-Aug       Impact factor: 17.165

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Authors:  R A Kloner; C E Ganote; R B Jennings
Journal:  J Clin Invest       Date:  1974-12       Impact factor: 14.808
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  3 in total

1.  Effects of pyruvate on post-ischemic myocardial recovery at various workloads.

Authors:  M van Bilsen; G J van der Vusse; L H Snoeckx; T Arts; W A Coumans; P H Willemsen; R S Reneman
Journal:  Pflugers Arch       Date:  1988-12       Impact factor: 3.657

2.  Reversibility of mild to moderate ischemic injuries in the isolated rat heart. A characterization by 31P-NMR and by physiological and ultrastructural indices.

Authors:  G Greve; O E Bakøy; T Holten; P Jynge; T Saetersdal
Journal:  Am J Pathol       Date:  1993-04       Impact factor: 4.307

3.  Osmotic changes and transsarcolemmal ion transport during total ischaemia of isolated rat ventricular myocytes.

Authors:  J W Fiolet; C A Schumacher; A Baartscheer; R Coronel
Journal:  Basic Res Cardiol       Date:  1993 Sep-Oct       Impact factor: 17.165
  3 in total

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