Experimental deep venous thrombogenesis by a non-invasive method.

Experimental deep venous thrombi were produced in the untraumatised leg veins of anaesthetised dogs. In place of trauma, the endothelium lining the valve pockets in femoral veins was damaged by hypoxaemia, and the pockets were then intermittently re-perfused with oxygenated blood. Histologically, the experimental thrombi resembled human valve pocket thrombi found at postmortem.