Literature DB >> 6504960

Potentiation of thermoregulatory and analgesic effects of morphine by calcium antagonists.

G Benedek, M Szikszay.   

Abstract

Diltiazem, a calcium slow channel blocker, greatly potentiated and prolonged the antinociceptive effect of morphine in rats. Hypothermia, the primary thermoregulatory effect of morphine, was also potentiated. Verapamil, another calcium blocker elicited corresponding changes in the analgetic and thermoregulatory effects of morphine. These findings seem to be in concert with the suggestions that opiate effects on thermoregulation and nociception are exerted via modulation of calcium fluxes across neural membranes.

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Year:  1984        PMID： 6504960     DOI： 10.1016/s0031-6989(84)80065-x

Source DB:  PubMed          Journal:  Pharmacol Res Commun        ISSN： 0031-6989


  12 in total

1.  Role of calcium channels in effects of antidepressant drugs on responsiveness to pain.

Authors:  L Antkiewicz-Michaluk; I Romańska; J Michaluk; J Vetulani
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

2.  Calcium channel blockers: effect on morphine-induced hypermotility.

Authors:  M I Martin; I Lizasoain; J C Leza
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

3.  Effect of repetitive electroconvulsive treatment on sensitivity to pain and on [3H]nitrendipine binding sites in cortical and hippocampal membranes.

Authors:  L Antkiewicz-Michaluk; J Michaluk; I Romańska; J Vetulani
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

4.  Calcium channel involvement in magnetic field inhibition of morphine-induced analgesia.

Authors:  M Kavaliers; K P Ossenkopp
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-09       Impact factor: 3.000

Review 5.  The role of excitatory amino acid receptors and intracellular messengers in persistent nociception after tissue injury in rats.

Authors:  T J Coderre
Journal:  Mol Neurobiol       Date:  1993 Fall-Winter       Impact factor: 5.590

6.  Calcium channel modulation by dihydropyridines modifies sufentanil-induced antinociception in acute and tolerant conditions.

Authors:  M Dierssen; J Flórez; M A Hurlé
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-11       Impact factor: 3.000

7.  Dexmedetomidine-induced decrease in cerebral blood flow is attenuated by verapamil in rats: a laser Doppler study.

Authors:  F Bari; G Horváth; G Benedek
Journal:  Can J Anaesth       Date:  1993-08       Impact factor: 5.063

8.  Magnetic fields inhibit opioid-mediated 'analgesic' behaviours of the terrestrial snail, Cepaea nemoralis.

Authors:  M Kavaliers; K P Ossenkopp
Journal:  J Comp Physiol A       Date:  1988-03       Impact factor: 1.836

9.  Potentiation of acute opioid-induced respiratory depression and reversal of tolerance by the calcium antagonist nimodipine in awake rats.

Authors:  F Ruiz; M Dierssen; J Flórez; M A Hurlé
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-12       Impact factor: 3.000

10.  Calcium agonists and antagonists of the dihydropyridine type: antinociceptive effects, interference with opiate-mu-receptor agonists and neuropharmacological actions in rodents.

Authors:  F Hoffmeister; D Tettenborn
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530
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