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Literature DB >> 6504137

Microtubule assembly nucleated by isolated centrosomes.

Abstract

Microtubules are involved in the morphogenesis of most cells and are the structural basis of the mitotic spindle. We report here that purified centrosomes nucleate the assembly of microtubules with unusual dynamic properties. This may have important implications for the mechanism by which microtubule arrays are organized and stabilized in cells.

Mesh：

Substances：
Polymers
Tubulin

Year: 1984 PMID： 6504137 DOI： 10.1038/312232a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

Keyword Cloud
Cited

213 in total

1. Differential association of tau with subsets of microtubules containing posttranslationally-modified tubulin variants in neuroblastoma cells.

Authors: L Saragoni; P Hernández; R B Maccioni
Journal: Neurochem Res Date: 2000-01 Impact factor: 3.996

2. Reconstitution and characterization of budding yeast gamma-tubulin complex.

Authors: Dani B N Vinh; Joshua W Kern; William O Hancock; Jonathon Howard; Trisha N Davis
Journal: Mol Biol Cell Date: 2002-04 Impact factor: 4.138

3. GCP5 and GCP6: two new members of the human gamma-tubulin complex.

Authors: S M Murphy; A M Preble; U K Patel; K L O'Connell; D P Dias; M Moritz; D Agard; J T Stults; T Stearns
Journal: Mol Biol Cell Date: 2001-11 Impact factor: 4.138

4. Incorporation of Paramecium axonemal tubulin into higher plant cells reveals functional sites of microtubule assembly.

Authors: M Vantard; N Levilliers; A M Hill; A Adoutte; A M Lambert
Journal: Proc Natl Acad Sci U S A Date: 1990-11 Impact factor: 11.205

5. Outer dense fiber 2 is a widespread centrosome scaffold component preferentially associated with mother centrioles: its identification from isolated centrosomes.

Authors: Y Nakagawa; Y Yamane; T Okanoue; S Tsukita; S Tsukita
Journal: Mol Biol Cell Date: 2001-06 Impact factor: 4.138

Microtubule assembly nucleated by isolated centrosomes.

1. Differential association of tau with subsets of microtubules containing posttranslationally-modified tubulin variants in neuroblastoma cells.

2. Reconstitution and characterization of budding yeast gamma-tubulin complex.

3. GCP5 and GCP6: two new members of the human gamma-tubulin complex.

4. Incorporation of Paramecium axonemal tubulin into higher plant cells reveals functional sites of microtubule assembly.

5. Outer dense fiber 2 is a widespread centrosome scaffold component preferentially associated with mother centrioles: its identification from isolated centrosomes.

6. Association of adenovirus with the microtubule organizing center.

7. Protein-DNA computation by stochastic assembly cascade.

8. Importin alpha-regulated nucleation of microtubules by TPX2.

9. Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

10. Differential regulation of maternal vs. paternal centrosomes.