Literature DB >> 6503025

Titration of botulinum toxins for lethal toxicity by intravenous injection into mice.

H Kondo, T Shimizu, M Kubonoya, N Izumi, M Takahashi, G Sakaguchi.   

Abstract

Clostridium botulinum type A - F toxins can be titrated by the time-to-death method by iv injection into mice. The time to death is not dependent upon the molecular size, but upon the immunological type of the toxin. It is necessary to assure complete activation of the activable toxin produced by nonproteolytic as well as a certain proteolytic strains before subjecting to titration by the iv injection method.

Entities:  

Mesh:

Substances:

Year:  1984        PMID: 6503025     DOI: 10.7883/yoken1952.37.131

Source DB:  PubMed          Journal:  Jpn J Med Sci Biol        ISSN: 0021-5112


  9 in total

1.  Immunological characterization of papain-induced fragments of Clostridium botulinum type A neurotoxin and interaction of the fragments with brain synaptosomes.

Authors:  S Kozaki; A Miki; Y Kamata; J Ogasawara; G Sakaguchi
Journal:  Infect Immun       Date:  1989-09       Impact factor: 3.441

2.  The use of monoclonal antibodies to analyze the structure of Clostridium botulinum type E derivative toxin.

Authors:  S Kozaki; Y Kamata; T Nagai; J Ogasawara; G Sakaguchi
Journal:  Infect Immun       Date:  1986-06       Impact factor: 3.441

3.  Antigenic structure of Clostridium botulinum type B neurotoxin and its interaction with gangliosides, cerebroside, and free fatty acids.

Authors:  S Kozaki; J Ogasawara; Y Shimote; Y Kamata; G Sakaguchi
Journal:  Infect Immun       Date:  1987-12       Impact factor: 3.441

4.  Induction of an immune response by oral administration of recombinant botulinum toxin.

Authors:  N Kiyatkin; A B Maksymowych; L L Simpson
Journal:  Infect Immun       Date:  1997-11       Impact factor: 3.441

5.  Rapid method for purification of Clostridium botulinum type C neurotoxin by high performance liquid chromatography (HPLC).

Authors:  M Matsuda; K Ozutsumi; P Y Du; N Sugimoto
Journal:  Eur J Epidemiol       Date:  1986-12       Impact factor: 8.082

6.  Characterization of Clostridium botulinum type B neurotoxin associated with infant botulism in japan.

Authors:  S Kozaki; Y Kamata; T Nishiki; H Kakinuma; H Maruyama; H Takahashi; T Karasawa; K Yamakawa; S Nakamura
Journal:  Infect Immun       Date:  1998-10       Impact factor: 3.441

7.  An Ultrasensitive Gold Nanoparticle-based Lateral Flow Test for the Detection of Active Botulinum Neurotoxin Type A.

Authors:  Jing Liu; Shan Gao; Lin Kang; Bin Ji; Wenwen Xin; Jingjing Kang; Ping Li; Jie Gao; Hanbin Wang; Jinglin Wang; Hao Yang
Journal:  Nanoscale Res Lett       Date:  2017-03-29       Impact factor: 4.703

Review 8.  Critical Analysis of Neuronal Cell and the Mouse Bioassay for Detection of Botulinum Neurotoxins.

Authors:  Sabine Pellett; William H Tepp; Eric A Johnson
Journal:  Toxins (Basel)       Date:  2019-12-07       Impact factor: 4.546

9.  Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B.

Authors:  Takuhiro Matsumura; Sho Amatsu; Ryo Misaki; Masahiro Yutani; Anariwa Du; Tomoko Kohda; Kazuhito Fujiyama; Kazuyoshi Ikuta; Yukako Fujinaga
Journal:  Toxins (Basel)       Date:  2020-05-07       Impact factor: 4.546

  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.