Literature DB >> 6502608

Synthesis and antitumor activity of tropolone derivatives.

M Yamato, K Hashigaki, N Kokubu, T Tsuruo, T Tashiro.   

Abstract

Treatment of tropolones with benzaldehyde diethyl acetals gave monotropolone (12) and bistropolone (13) derivatives at the benzylic position, whereas the related 1-ethoxyisochroman and the diethyl acetals of crotonaldehyde and cinnamaldehyde gave only the monotropolone derivatives (5, 10, or 11). The monotropolone derivatives (5, 10, 11, and 12) had poor potency against P388 leukemia in mice, but the bistropolone derivatives (13 and 14) showed significant potency and prolongation of life.

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Year:  1984        PMID： 6502608     DOI： 10.1021/jm00378a041

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  3 in total

1.  Total Synthesis and Computational Investigations of Sesquiterpene-Tropolones Ameliorate Stereochemical Inconsistencies and Resolve an Ambiguous Biosynthetic Relationship.

Authors:  Christopher Y Bemis; Chad N Ungarean; Alexander S Shved; Cooper S Jamieson; Taehwan Hwang; Ken S Lee; K N Houk; David Sarlah
Journal:  J Am Chem Soc       Date:  2021-04-07       Impact factor: 16.383

2.  Imbalance of deoxyribonucleoside triphosphates and DNA double-strand breaks in mouse mammary tumor FM3A cells treated in vitro with an antineoplastic tropolone derivative.

Authors:  M Yamato; Y Hirota; S Yoshida; S Tanaka; T Morita; J Sakai; K Hashigaki; H Hayatsu; Y Wataya
Journal:  Jpn J Cancer Res       Date:  1992-06

3.  2-Hetaryl-1,3-tropolones based on five-membered nitrogen heterocycles: synthesis, structure and properties.

Authors:  Yury A Sayapin; Inna O Tupaeva; Alexandra A Kolodina; Eugeny A Gusakov; Vitaly N Komissarov; Igor V Dorogan; Nadezhda I Makarova; Anatoly V Metelitsa; Valery V Tkachev; Sergey M Aldoshin; Vladimir I Minkin
Journal:  Beilstein J Org Chem       Date:  2015-11-12       Impact factor: 2.883
  3 in total

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