Literature DB >> 6501296

Gamma-carboxyglutamate in a neuroactive toxin.

J M McIntosh, B M Olivera, L J Cruz, W R Gray.   

Abstract

The venom of a fish-hunting cone snail (Conus geographus) contains a novel toxin, the "sleeper" peptide, which induces a sleep-like state in mice when injected intracerebrally. We demonstrate that this peptide contains 5 mol of gamma-carboxyglutamate (Gla) in 17 amino acids. The amino acid sequence of the sleeper peptide is Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2.

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Year:  1984        PMID： 6501296

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  33 in total

1.  Efficient oxidative folding of conotoxins and the radiation of venomous cone snails.

Authors:  Grzegorz Bulaj; Olga Buczek; Ian Goodsell; Elsie C Jimenez; Jessica Kranski; Jacob S Nielsen; James E Garrett; Baldomero M Olivera
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-22       Impact factor: 11.205

2.  [M + Fe - 5H]2- peptide ion composition verified by Fourier transform mass spectrometry accurate mass and tandem mass spectrometry analyses.

Authors:  A G Craig; J P Speir; S Rosamilia; V Fursey; M B Lirazan
Journal:  J Am Soc Mass Spectrom       Date:  2000-01       Impact factor: 3.109

3.  Characterization of the peptidylglycine α-amidating monooxygenase (PAM) from the venom ducts of neogastropods, Conus bullatus and Conus geographus.

Authors:  Sabah Ul-Hasan; Daniel M Burgess; Joanna Gajewiak; Qing Li; Hao Hu; Mark Yandell; Baldomero M Olivera; Pradip K Bandyopadhyay
Journal:  Toxicon       Date:  2013-08-29       Impact factor: 3.033

4.  Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits.

Authors:  Konkallu Hanumae Gowd; Tiffany S Han; Vernon Twede; Joanna Gajewiak; Misty D Smith; Maren Watkins; Randall J Platt; Gabriela Toledo; H Steve White; Baldomero M Olivera; Grzegorz Bulaj
Journal:  Biochemistry       Date:  2012-05-30       Impact factor: 3.162

5.  Proteomic analysis provides insights on venom processing in Conus textile.

Authors:  Lemmuel L Tayo; Bingwen Lu; Lourdes J Cruz; John R Yates
Journal:  J Proteome Res       Date:  2010-05-07       Impact factor: 4.466

Review 6.  Structural determinants of protein folding.

Authors:  Tse Siang Kang; R Manjunatha Kini
Journal:  Cell Mol Life Sci       Date:  2009-04-15       Impact factor: 9.261

7.  gamma -Glutamyl carboxylation: An extracellular posttranslational modification that antedates the divergence of molluscs, arthropods, and chordates.

Authors:  Pradip K Bandyopadhyay; James E Garrett; Reshma P Shetty; Tyler Keate; Craig S Walker; Baldomero M Olivera
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-29       Impact factor: 11.205

8.  Conantokin-P, an unusual conantokin with a long disulfide loop.

Authors:  Konkallu Hanumae Gowd; Vernon Twede; Maren Watkins; K S Krishnan; Russell W Teichert; Grzegorz Bulaj; Baldomero M Olivera
Journal:  Toxicon       Date:  2008-06-03       Impact factor: 3.033

Review 9.  Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase.

Authors:  C Vermeer
Journal:  Biochem J       Date:  1990-03-15       Impact factor: 3.857

Review 10.  Ligands for ionotropic glutamate receptors.

Authors:  Geoffrey T Swanson; Ryuichi Sakai
Journal:  Prog Mol Subcell Biol       Date:  2009
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