Literature DB >> 6501109

Empedopeptin (BMY-28117), a new depsipeptide antibiotic. II. Structure determination.

K Sugawara, K Numata, M Konishi, H Kawaguchi.   

Abstract

Structure of a new antibiotic, empedopeptin, has been determined. It is a cyclic depsipeptide composed of two mol of D-serine and one mol each of beta-hydroxytetradecanoic acid, L-arginine, D- and L-proline, L-3-hydroxyproline and D- and L-beta-hydroxyaspartic acid. The sequence of these moieties was established by partial hydrolysis and mass spectral analysis of the antibiotic.

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Year:  1984        PMID： 6501109     DOI： 10.7164/antibiotics.37.958

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  4 in total

1.  Tripropeptin C blocks the lipid cycle of cell wall biosynthesis by complex formation with undecaprenyl pyrophosphate.

Authors:  Hideki Hashizume; Ryuichi Sawa; Shigeko Harada; Masayuki Igarashi; Hayamitsu Adachi; Yoshio Nishimura; Akio Nomoto
Journal:  Antimicrob Agents Chemother       Date:  2011-05-31       Impact factor: 5.191

2.  Characterization of a Novel cis-3-Hydroxy-l-Proline Dehydratase and a trans-3-Hydroxy-l-Proline Dehydratase from Bacteria.

Authors:  Seiya Watanabe; Fumiyasu Fukumori; Mao Miyazaki; Shinya Tagami; Yasuo Watanabe
Journal:  J Bacteriol       Date:  2017-07-25       Impact factor: 3.490

3.  Lipodepsipeptide empedopeptin inhibits cell wall biosynthesis through Ca2+-dependent complex formation with peptidoglycan precursors.

Authors:  Anna Müller; Daniela Münch; Yvonne Schmidt; Katrin Reder-Christ; Guido Schiffer; Gerd Bendas; Harald Gross; Hans-Georg Sahl; Tanja Schneider; Heike Brötz-Oesterhelt
Journal:  J Biol Chem       Date:  2012-04-18       Impact factor: 5.157

4.  The Draft Whole-Genome Sequence of the Antibiotic Producer Empedobacter haloabium ATCC 31962 Provides Indications for Its Taxonomic Reclassification.

Authors:  Henrike Miess; Patricia Arlt; Alexander Kristian Apel; Tilmann Weber; Kay Nieselt; Friederike Hanssen; Stefan Czemmel; Sven Nahnsen; Harald Gross
Journal:  Microbiol Resour Announc       Date:  2019-11-07
  4 in total

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