Literature DB >> 6501108

Empedopeptin (BMY-28117), a new depsipeptide antibiotic. I. Production, isolation and properties.

M Konishi, K Sugawara, M Hanada, K Tomita, K Tomatsu, T Miyaki, H Kawaguchi, R E Buck, C More, V Z Rossomano.   

Abstract

Empedopeptin is a new antibiotic produced by empedobacter haloabium nov. sp. (ATCC 31962). It is a water-soluble depsipeptide antibiotic containing eight amino acid residues and a C14-fatty acid moiety in the molecule. Although structurally unrelated, empedopeptin and vancomycin have similar antimicrobial spectra against aerobic and anaerobic Gram-positive bacteria including antibiotic-resistant strains. Empedopeptin is highly active in vivo in mice against systemic infections of Staphylococcus aureus, Streptococcus pyogenes and Clostridium perfringens. Empedopeptin is not absorbed orally.

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Year:  1984        PMID： 6501108     DOI： 10.7164/antibiotics.37.949

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

Review 1.  Targeting the Achilles' Heel of Bacteria: Different Mechanisms To Break Down the Peptidoglycan Cell Wall during Bacterial Warfare.

Authors:  Stephanie Sibinelli-Sousa; Julia Takuno Hespanhol; Ethel Bayer-Santos
Journal:  J Bacteriol       Date:  2021-03-08       Impact factor: 3.490

2.  Tripropeptin C blocks the lipid cycle of cell wall biosynthesis by complex formation with undecaprenyl pyrophosphate.

Authors:  Hideki Hashizume; Ryuichi Sawa; Shigeko Harada; Masayuki Igarashi; Hayamitsu Adachi; Yoshio Nishimura; Akio Nomoto
Journal:  Antimicrob Agents Chemother       Date:  2011-05-31       Impact factor: 5.191

Review 3.  Advances in MRSA drug discovery: where are we and where do we need to be?

Authors:  Michio Kurosu; Shajila Siricilla; Katsuhiko Mitachi
Journal:  Expert Opin Drug Discov       Date:  2013-07-06       Impact factor: 6.098

4.  Lipodepsipeptide empedopeptin inhibits cell wall biosynthesis through Ca2+-dependent complex formation with peptidoglycan precursors.

Authors:  Anna Müller; Daniela Münch; Yvonne Schmidt; Katrin Reder-Christ; Guido Schiffer; Gerd Bendas; Harald Gross; Hans-Georg Sahl; Tanja Schneider; Heike Brötz-Oesterhelt
Journal:  J Biol Chem       Date:  2012-04-18       Impact factor: 5.157

5.  The Draft Whole-Genome Sequence of the Antibiotic Producer Empedobacter haloabium ATCC 31962 Provides Indications for Its Taxonomic Reclassification.

Authors:  Henrike Miess; Patricia Arlt; Alexander Kristian Apel; Tilmann Weber; Kay Nieselt; Friederike Hanssen; Stefan Czemmel; Sven Nahnsen; Harald Gross
Journal:  Microbiol Resour Announc       Date:  2019-11-07

6.  Integrated Omics Strategy Reveals Cyclic Lipopeptides Empedopeptins from Massilia sp. YMA4 and Their Biosynthetic Pathway.

Authors:  Shang-Tse Ho; Ying-Ning Ho; Chih Lin; Wei-Chen Hsu; Han-Jung Lee; Chia-Chi Peng; Han-Tan Cheng; Yu-Liang Yang
Journal:  Mar Drugs       Date:  2021-04-09       Impact factor: 5.118
  6 in total

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