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Literature DB >> 6500556

HLA as a marker of the hemochromatosis gene in Sweden.

Abstract

The frequency of HLA-A3 and HLA-B14 antigens was found to be significantly (P = less than 0.0001) higher in a series of 50 unrelated and unselected Swedish patients with idiopathic hemochromatosis (IH) than in controls, being 66% and 32% for A3 and 22% and 2% for B14. The haplotype A3B14 was associated with the highest risk in this material (relative risk 23.4). One family with this haplotype was traced back to the end of the seventeenth century. The pattern of HLA antigens associated with IH in Sweden shows remarkable similarity to those reported from England and Brittany.

Entities: Disease Gene Species

Mesh：

Substances：
HLA Antigens

Year: 1984 PMID： 6500556 DOI： 10.1007/bf00293874

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

32 in total

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Authors: B WOOLF
Journal: Ann Hum Genet Date: 1955-06 Impact factor: 1.670

2. Separation of leukocytes from blood and bone marrow. Introduction.

Authors: A Böyum
Journal: Scand J Clin Lab Invest Suppl Date: 1968

3. Histocompatibility antigens as markers of abnormal iron metabolism in idiopathic hemochromatosis.

Authors: D A Lloyd; P Adams; N R Sinclair; C R Stiller; L S Valberg
Journal: Can Med Assoc J Date: 1978-11-04 Impact factor: 8.262

4. Histocompatibility antigens as markers of abnormal iron metabolism in patients with idiopathic haemochromatosis and their relatives.

Authors: A Bomford; A L Eddleston; L A Kennedy; J R Batchelor; R Williams
Journal: Lancet Date: 1977-02-12 Impact factor: 79.321

5. Association of HLA antigens with idopathic hemochromatosis.

Authors: P Laukens; J Versieck; E De Potter; F Barbier
Journal: Gastroenterology Date: 1978-06 Impact factor: 22.682

6. HLA antigens in patients with idiopathic hemochromatosis (IH).

Authors: P Kühnl; J P Kaltwasser; S Seidl
Journal: Tissue Antigens Date: 1978-11

7. Genetics of hemochromatosis.

Authors: A G Motulsky
Journal: N Engl J Med Date: 1979-12-06 Impact factor: 91.245

8. Idiopathic haemochromatosis in the Australian population: HLA linkage and recessivity.

Authors: T J Doran; H V Bashir; J Trejaut; M L Bassett; J W Halliday; L W Powell
Journal: Hum Immunol Date: 1981-05 Impact factor: 2.850

9. Idiopathic hemochromatosis: a study of biochemical expression in 247 heterozygous members of 63 families: evidence for a single major HLA-linked gene.

Authors: M Simon; R Fauchet; J P Hespel; C Beaumont; P Brissot; B Hery; Y Hita De Nercy; B Genetet; M Bourel
Journal: Gastroenterology Date: 1980-04 Impact factor: 22.682

10. Homozygosity for hemochromatosis: clinical manifestations.

Authors: C Q Edwards; G E Cartwright; M H Skolnick; D B Amos
Journal: Ann Intern Med Date: 1980-10 Impact factor: 25.391

8 in total

1. Idiopathic haemochromatosis in north Portugal: association with haplotype A3B7.

Authors: G Porto; B M da Silva; C Vincente; M de Sousa
Journal: J Clin Pathol Date: 1989-06 Impact factor: 3.411

2. A study of 609 HLA haplotypes marking for the hemochromatosis gene: (1) mapping of the gene near the HLA-A locus and characters required to define a heterozygous population and (2) hypothesis concerning the underlying cause of hemochromatosis-HLA association.

Authors: M Simon; L Le Mignon; R Fauchet; J Yaouanq; V David; G Edan; M Bourel
Journal: Am J Hum Genet Date: 1987-08 Impact factor: 11.025

HLA as a marker of the hemochromatosis gene in Sweden.

1. On estimating the relation between blood group and disease.

2. Separation of leukocytes from blood and bone marrow. Introduction.

3. Histocompatibility antigens as markers of abnormal iron metabolism in idiopathic hemochromatosis.

4. Histocompatibility antigens as markers of abnormal iron metabolism in patients with idiopathic haemochromatosis and their relatives.

5. Association of HLA antigens with idopathic hemochromatosis.

6. HLA antigens in patients with idiopathic hemochromatosis (IH).

7. Genetics of hemochromatosis.

8. Idiopathic haemochromatosis in the Australian population: HLA linkage and recessivity.

9. Idiopathic hemochromatosis: a study of biochemical expression in 247 heterozygous members of 63 families: evidence for a single major HLA-linked gene.

10. Homozygosity for hemochromatosis: clinical manifestations.

1. Idiopathic haemochromatosis in north Portugal: association with haplotype A3B7.

2. A study of 609 HLA haplotypes marking for the hemochromatosis gene: (1) mapping of the gene near the HLA-A locus and characters required to define a heterozygous population and (2) hypothesis concerning the underlying cause of hemochromatosis-HLA association.

3. Transferrin types and expression of hereditary hemochromatosis.

4. Mapping the locus for hereditary hemochromatosis: localization between HLA-B and HLA-A.

5. HLA determinants in an Australian population of hemochromatosis patients and their families.

6. HLA antigens in Hungarian patients with idiopathic haemochromatosis.

7. HLA-A and -B alleles and haplotypes in hemochromatosis probands with HFE C282Y homozygosity in central Alabama.

8. HLA haplotypes associated with hemochromatosis mutations in the Spanish population.