Literature DB >> 6498804

Rapid lipid peroxidation in the nuclear fraction of rat liver induced by a diet deficient in choline and methionine.

T H Rushmore, Y P Lim, E Farber, A K Ghoshal.   

Abstract

A diet deficient in choline and methionine, known to produce hepatocellular carcinoma in the absence of any added chemical carcinogen, induced lipid peroxidation in the nuclear fraction of the liver when fed to male Fischer 344 rats. This lipid peroxidation was detected within 1 day of feeding the diet by the appearance of diene conjugates and increased progressively up to 3 days. It was prevented completely by the addition of choline chloride to the diet. The close proximity of DNA may make it a possible target for attack by free radicals.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6498804     DOI： 10.1016/0304-3835(84)90020-x

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  12 in total

1.  Response of urinary malondialdehyde to factors that stimulate lipid peroxidation in vivo.

Authors:  S N Dhanakoti; H H Draper
Journal:  Lipids       Date:  1987-09       Impact factor: 1.880

2.  Changes in fatty acid composition of phospholipids from liver microsomes and nuclei in rats fed a choline-free diet.

Authors:  R Kapoor; A K Ghoshal; E Farber
Journal:  Lipids       Date:  1992-02       Impact factor: 1.880

3.  Choline deficiency increases lymphocyte apoptosis and DNA damage in humans.

Authors:  Kerry-Ann da Costa; Mihai D Niculescu; Corneliu N Craciunescu; Leslie M Fischer; Steven H Zeisel
Journal:  Am J Clin Nutr       Date:  2006-07       Impact factor: 7.045

4.  Detection of exocyclic 1,N2-propanodeoxyguanosine adducts as common DNA lesions in rodents and humans.

Authors:  R G Nath; F L Chung
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-02       Impact factor: 11.205

Review 5.  Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones.

Authors:  Steven H Zeisel
Journal:  Mutat Res       Date:  2011-10-20       Impact factor: 2.433

6.  Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas.

Authors:  Ya-Wen Teng; Mihai G Mehedint; Timothy A Garrow; Steven H Zeisel
Journal:  J Biol Chem       Date:  2011-08-30       Impact factor: 5.157

7.  Nonalcoholic steatohepatitis (NASH) in ob/ob mice treated with yo jyo hen shi ko (YHK): effects on peroxisome proliferator-activated receptors (PPARs) and microsomal triglyceride transfer protein (MTP).

Authors:  José Tadeu Stefano; Claudia Pinto Marques Souza de Oliveira; Maria Lúcia Corrêa-Giannella; Vicência Mara Rodrigues de Lima; Sandra Valéria de Sá; Ellen Pierre de Oliveira; Evandro Sobroza de Mello; Daniel Giannella-Neto; Venâncio Avancini Ferreira Alves; Flair José Carrilho
Journal:  Dig Dis Sci       Date:  2007-03-30       Impact factor: 3.199

8.  Repair kinetics of trans-4-hydroxynonenal-induced cyclic 1,N2-propanodeoxyguanine DNA adducts by human cell nuclear extracts.

Authors:  Sujata Choudhury; Jishen Pan; Shantu Amin; Fung-Lung Chung; Rabindra Roy
Journal:  Biochemistry       Date:  2004-06-15       Impact factor: 3.162

9.  Free-radical-mediated DNA binding.

Authors:  P J O'Brien
Journal:  Environ Health Perspect       Date:  1985-12       Impact factor: 9.031

10.  Choline deficient diet enhances the initiating and promoting effects of methapyrilene hydrochloride in rat liver as assayed by the induction of gamma-glutamyltranspeptidase-positive hepatocyte foci.

Authors:  M I Perera; S L Katyal; H Shinozuka
Journal:  Br J Cancer       Date:  1987-12       Impact factor: 7.640
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.