Nonrandom chromosome changes in carcinoma of the cervix uteri. II. Ten tumors in the triploid-tetraploid range.

Nonrandom chromosome changes in direct preparations of 10 cervical carcinomas with modal numbers in the range of 60-82 were similar to those found in a previous study on near-diploid tumors: Chromosomes 1 (seven tumors) and 11 (five tumors) were most often involved in structural rearrangements and a small metacentric, often present in duplicate, was seen in six tumors. The appearances of the small metacentric again suggested an origin from a chromosome #4 or #5: either a long arm deletion or a short arm isochromosome; in one tumor, Giemsa-11 banding was more compatible with a #4 than a #5. Chromosome #17 anomalies were probably present in four tumors, and two tumors had markers, probably derived from chromosome #2, containing homogeneously staining regions.