| Literature DB >> 6498616 |
T Inaba, M Nakano, S V Otton, W A Mahon, W Kalow.
Abstract
The present study compares the debrisoquine monooxygenase and the sparteine monooxygenase activities of human liver microsomes. In the presence of 14 competitive inhibitors, apparent inhibition constants (Ki) as determined by these two activities ranged over four orders of magnitude with a correlation coefficient 0.99. These in vitro results represent the strongest evidence to date that the debrisoquine monooxygenase and the sparteine monooxygenase are identical and involve a single isozyme of cytochrome P-450.Entities:
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Year: 1984 PMID： 6498616 DOI： 10.1139/y84-144
Source DB: PubMed Journal: Can J Physiol Pharmacol ISSN： 0008-4212 Impact factor: 2.273