Literature DB >> 6498117

Biological monitoring of workers exposed to 4,4'-methylenebis (2-chloroaniline) (MBOCA).

J D Thomas, H K Wilson.   

Abstract

A biological monitoring programme has been developed for assessing occupational exposure to 4,4'-methylenebis (2-chloroaniline) (MBOCA) in a factory which manufactures polyurethane elastomers. In a systematic programme of biological monitoring over a five year period urinary MBOCA concentrations have been used to provide evidence of absorption of MBOCA. Improvements in the handling and use of MBOCA have coincided with a steady reduction in the urinary MBOCA concentrations.

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Year:  1984        PMID： 6498117      PMCID： PMC1009383          DOI： 10.1136/oem.41.4.547

Source DB:  PubMed          Journal:  Br J Ind Med        ISSN： 0007-1072


  11 in total

1.  The carcinogenic effect of 4,4'-methylene-bis-(2-chloroaniline) in mice and rats.

Authors:  A B Russfield; F Homburger; E Boger; C G Van Dongen; E K Weisburger; J H Weisburger
Journal:  Toxicol Appl Pharmacol       Date:  1975-01       Impact factor: 4.219

2.  Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

Authors:  J McCann; E Choi; E Yamasaki; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

3.  Precautions in the use of methylene-bis-omicron-chloroaniline (MBOCA).

Authors:  H F Henning
Journal:  Ann Occup Hyg       Date:  1974-12

4.  Benzidine exposure as a cause of bladder tumors.

Authors:  M R Zavon; U Hoegg; E Bingham
Journal:  Arch Environ Health       Date:  1973-07

5.  Methylene-bis-ortho-chloroaniline (MOCA): evaluation of hazards and exposure control.

Authors:  A L Linch; G B O'Connor; J R Barnes; A S Killian; W E Neeld
Journal:  Am Ind Hyg Assoc J       Date:  1971-12

6.  The genotoxicity of 4,4'-methylenebis-2-chloroaniline in rat, mouse, and hamster hepatocytes.

Authors:  C A McQueen; C J Maslansky; S B Crescenzi; G M Williams
Journal:  Toxicol Appl Pharmacol       Date:  1981-04       Impact factor: 4.219

7.  Urinary bladder tumors in dogs from 4,4'-methylene-bis (2-chloroaniline) (MOCA).

Authors:  E F Stula; J R Barnes; H Sherman; C F Reinhardt; J A Zapp
Journal:  J Environ Pathol Toxicol       Date:  1978 Sep-Oct

8.  Liver and lung tumors in dogs from 4,4'-methylene-bis(2-methylaniline).

Authors:  E F Stula; J R Barnes; H Sherman; C F Reinhardt; J A Zapp
Journal:  J Environ Pathol Toxicol       Date:  1978 Jan-Feb

9.  Acute exposure to methylene-bis-ortho chloroaniline (MOCA).

Authors:  H R Hosein; P B Van Roosmalen
Journal:  Am Ind Hyg Assoc J       Date:  1978-06

10.  Determination of the tumorigenic potential of methylene-bis-orthochloroaniline.

Authors:  C Kommineni; D H Groth; I J Frockt; R W Voelker; R P Stanovick
Journal:  J Environ Pathol Toxicol       Date:  1979 May-Jun
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  5 in total

Review 1.  Comprehensive evaluation of long-term trends in occupational exposure: Part 1. Description of the database.

Authors:  E Symanski; L L Kupper; S M Rappaport
Journal:  Occup Environ Med       Date:  1998-05       Impact factor: 4.402

2.  Unlabeled hemoglobin adducts of 4,4'-methylenebis (2-chloroaniline) in rats and guinea pigs.

Authors:  T H Chen; B I Kuslikis; W E Braselton
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

3.  Evidence that a beta-N-glucuronide of 4,4'-methylenebis (2-chloroaniline) (MbOCA) is a major urinary metabolite in man: implications for biological monitoring.

Authors:  J Cocker; A R Boobis; H K Wilson; D Gompertz
Journal:  Br J Ind Med       Date:  1990-03

4.  Assessment of occupational exposure to 4,4'-diaminodiphenylmethane (methylene dianiline) by gas chromatography-mass spectrometry analysis of urine.

Authors:  J Cocker; W Gristwood; H K Wilson
Journal:  Br J Ind Med       Date:  1986-09

5.  Monitoring exposure to 4,4'-methylene-bis(2-chloroaniline) through the gas chromatography-mass spectrometry measurement of adducts to hemoglobin.

Authors:  E Bailey; A G Brooks; P B Farmer; B Street
Journal:  Environ Health Perspect       Date:  1993-03       Impact factor: 9.031
  5 in total

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