Literature DB >> 649639

Cefazolin concentrations in bone and synovial fluid.

D J Schurman, H P Hirshman, G Kajiyama, K Moser, D S Burton.   

Abstract

A single intravenous dose of one gram of cefazolin was administered prophylactically to forty-eight patients undergoing total joint replacement. The serum half-life of the antibiotic was 1.8 hours, the same value found in normal volunteers. The mean concentration in bone during surgery was 5.7 micrograms per gram of bone. The mean concentration in synovial fluid during surgery was 24.4 micrograms per milliliter of fluid.

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Year:  1978        PMID： 649639

Source DB:  PubMed          Journal:  J Bone Joint Surg Am        ISSN： 0021-9355            Impact factor:   5.284


  20 in total

1.  Higher cefazolin concentrations with intraosseous regional prophylaxis in TKA.

Authors:  Simon W Young; Mei Zhang; Joshua T Freeman; Kelly G Vince; Brendan Coleman
Journal:  Clin Orthop Relat Res       Date:  2013-01       Impact factor: 4.176

2.  Antibiotic-tolerant Staphylococcus aureus Biofilm Persists on Arthroplasty Materials.

Authors:  Kenneth L Urish; Peter W DeMuth; Brian W Kwan; David W Craft; Dongzhu Ma; Hani Haider; Rocky S Tuan; Thomas K Wood; Charles M Davis
Journal:  Clin Orthop Relat Res       Date:  2016-07       Impact factor: 4.176

Review 3.  Pharmacokinetic optimisation of the treatment of septic arthritis.

Authors:  K A Hamed; J Y Tam; C G Prober
Journal:  Clin Pharmacokinet       Date:  1996-08       Impact factor: 6.447

4.  Staphylococcal persistence due to biofilm formation in synovial fluid containing prophylactic cefazolin.

Authors:  Sana S Dastgheyb; Sommer Hammoud; Constantinos Ketonis; Andrew Yongkun Liu; Keith Fitzgerald; Javad Parvizi; James Purtill; Michael Ciccotti; Irving M Shapiro; Michael Otto; Noreen J Hickok
Journal:  Antimicrob Agents Chemother       Date:  2015-01-26       Impact factor: 5.191

5.  Reinfected revised TKA resolves with an aggressive protocol and antibiotic infusion.

Authors:  Leo A Whiteside; Tariq A Nayfeh; Renee LaZear; Marcel E Roy
Journal:  Clin Orthop Relat Res       Date:  2012-01       Impact factor: 4.176

6.  Skeletal muscle and plasma concentrations of cefazolin.

Authors:  P C Jutte; J J W Ploegmakers; S K Bulstra
Journal:  Br J Anaesth       Date:  2016-07       Impact factor: 9.166

7.  Vancomycin concentrations in infected and noninfected human bone.

Authors:  A L Graziani; L A Lawson; G A Gibson; M A Steinberg; R R MacGregor
Journal:  Antimicrob Agents Chemother       Date:  1988-09       Impact factor: 5.191

8.  Population Pharmacokinetic and Pharmacodynamic Target Attainment Analysis of Cefazolin in the Serum and Hip Joint Capsule of Patients Undergoing Total Hip Arthroplasty.

Authors:  Toshiaki Komatsu; Yui Natsume; Katsufumi Uchiyama; Shinsuke Ikeda; Yoshinori Tomoda; Yoko Takayama; Masashi Takaso; Hideaki Hanaki; Koichiro Atsuda
Journal:  Antimicrob Agents Chemother       Date:  2021-03-18       Impact factor: 5.191

9.  Methicillin-resistant Staphylococcus aureus in TKA treated with revision and direct intra-articular antibiotic infusion.

Authors:  Leo A Whiteside; Michael Peppers; Tariq A Nayfeh; Marcel E Roy
Journal:  Clin Orthop Relat Res       Date:  2011-01       Impact factor: 4.176

10.  Infected hip prostheses.

Authors:  S P Hughes
Journal:  Br Med J       Date:  1980-07-19
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