Literature DB >> 6494239

Biliary and renal excretion of paracetamol in man.

C P Siegers, W Loeser, J Gieselmann, D Oltmanns.   

Abstract

In 6 postsurgery patients with T tubes inserted in their common bile ducts, biliary excretion of paracetamol amounted to 2.6% of an oral dose (1 g), consisting of unchanged paracetamol (0.57%) and conjugates of sulfate (0.36%), glucuronic acid (0.36%) and cysteine (1.63%). Renal recovery in the same patients was 35.3%, consisting of 2.6% unchanged paracetamol, 12.7% paracetamol sulfate, 9.0% glucuronide, 3.9% cysteine conjugate and 4.0% mercapturate.

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Year:  1984        PMID： 6494239     DOI： 10.1159/000138026

Source DB:  PubMed          Journal:  Pharmacology        ISSN： 0031-7012            Impact factor:   2.547


  6 in total

Review 1.  Paracetamol: new vistas of an old drug.

Authors:  Alfio Bertolini; Anna Ferrari; Alessandra Ottani; Simona Guerzoni; Raffaella Tacchi; Sheila Leone
Journal:  CNS Drug Rev       Date:  2006 Fall-Winter

2.  Is biliary excretion of paracetamol significant in man?

Authors:  K S Jayasinghe; C J Roberts; A E Read
Journal:  Br J Clin Pharmacol       Date:  1986-09       Impact factor: 4.335

Review 3.  Methods to evaluate biliary excretion of drugs in humans: an updated review.

Authors:  Giulia Ghibellini; Elaine M Leslie; Kim L R Brouwer
Journal:  Mol Pharm       Date:  2006 May-Jun       Impact factor: 4.939

4.  Neonatal Maturation of Paracetamol (Acetaminophen) Glucuronidation, Sulfation, and Oxidation Based on a Parent-Metabolite Population Pharmacokinetic Model.

Authors:  Sarah F Cook; Chris Stockmann; Samira Samiee-Zafarghandy; Amber D King; Nina Deutsch; Elaine F Williams; Diana G Wilkins; Catherine M T Sherwin; John N van den Anker
Journal:  Clin Pharmacokinet       Date:  2016-11       Impact factor: 6.447

5.  Pentose pathway in human liver.

Authors:  I Magnusson; V Chandramouli; W C Schumann; K Kumaran; J Wahren; B R Landau
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

6.  Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometries.

Authors:  Abhishek Srivastava; Lu-Yun Lian; James L Maggs; Masautso Chaponda; Munir Pirmohamed; Dominic P Williams; B Kevin Park
Journal:  Drug Metab Dispos       Date:  2010-01       Impact factor: 3.922
  6 in total

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