Literature DB >> 6493247

Characterization of an unscheduled DNA synthesis assay with Syrian hamster embryo cells.

T Tsutsui, N Suzuki, H Maizumi, J C Barrett.   

Abstract

The Syrian hamster embryo cell transformation assay is widely used for studies of carcinogenesis. The characterization of an unscheduled DNA synthesis (UDS) assay for these cells is reported. Benzo[a]pyrene, aflatoxin B1 and UV light induced UDS in the cells in a dose-dependent manner without exogenous metabolic activity. Nitrosopiperidine induced UDS as well as gene mutations and cell transformation only in the presence of an exogenous metabolic activation system. The utility of this UDS assay with these cells is discussed.

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Year:  1984        PMID： 6493247     DOI： 10.1016/0027-5107(84)90129-5

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  5 in total

1.  In vitro chromosome aberration tests using human dental pulp cells to detect the carcinogenic potential of chemical agents.

Authors:  Takeo W Tsutsui; Tomohiro Inaba; Larry W Fisher; Pamela Gehron Robey; Takeki Tsutsui
Journal:  Odontology       Date:  2006-09       Impact factor: 2.634

2.  Assessment using human dental pulp cells of clastogenicity of antiseptics used in dental practice and agents for root canal enlargement and cleaning.

Authors:  Itsuro Hori; Yukari Higo; Maki Ohno; Takeo W Tsutsui; Takeki Tsutsui
Journal:  Odontology       Date:  2007-07-25       Impact factor: 2.634

3.  Non-genotoxicity of acrylic acid and n-butyl acrylate in a mammalian cell system (SHE cells).

Authors:  H J Wiegand; D Schiffmann; D Henschler
Journal:  Arch Toxicol       Date:  1989       Impact factor: 5.153

4.  Induction of unscheduled DNA synthesis and micronucleus formation in Syrian hamster embryo fibroblasts treated with cysteine S-conjugates of chlorinated hydrocarbons.

Authors:  S Vamvakas; W Dekant; D Schiffmann; D Henschler
Journal:  Cell Biol Toxicol       Date:  1988-12       Impact factor: 6.691

5.  Simultaneous measurement of unscheduled and replicating DNA synthesis by means of a new cell culture insert DNA retention method: rapid induction of replicating DNA synthesis in response to genotoxic carcinogens.

Authors:  A Okumura; T Tanaka; H Mori
Journal:  Jpn J Cancer Res       Date:  1996-08
  5 in total

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