Literature DB >> 6492889

Mutation frequency in human lymphocytes increases with age.

K J Trainor, D J Wigmore, A Chrysostomou, J L Dempsey, R Seshadri, A A Morley.   

Abstract

Several theories of ageing predict that somatic mutations should increase with age. This prediction was tested for human lymphocytes using a recently developed clonal technique for enumeration of mutations, and an increase of 1.6% per year in mutations with age was detected.

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Mesh：

Year:  1984        PMID： 6492889     DOI： 10.1016/0047-6374(84)90084-8

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


  16 in total

1.  Influence of sex, smoking and age on human hprt mutation frequencies and spectra.

Authors:  J Curry; L Karnaoukhova; G C Guenette; B W Glickman
Journal:  Genetics       Date:  1999-07       Impact factor: 4.562

Review 2.  Somatic mutations in aging, cancer and neurodegeneration.

Authors:  Scott R Kennedy; Lawrence A Loeb; Alan J Herr
Journal:  Mech Ageing Dev       Date:  2011-11-03       Impact factor: 5.432

3.  Chromosomes of older humans are more prone to aminopterine-induced breakage.

Authors:  D Esposito; G Fassina; P Szabo; P De Angelis; L Rodgers; M Weksler; M Siniscalco
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205

4.  Interindividual variation in mitotic recombination.

Authors:  D Holt; M Dreimanis; M Pfeiffer; F Firgaira; A Morley; D Turner
Journal:  Am J Hum Genet       Date:  1999-11       Impact factor: 11.025

5.  Unique tissue-specific level of DNA nucleotide excision repair in primary human mammary epithelial cultures.

Authors:  Jean J Latimer; Tariq Nazir; Lisa C Flowers; Michael J Forlenza; Kelly Beaudry-Rodgers; Crystal M Kelly; Julie A Conte; Kenneth Shestak; Amal Kanbour-Shakir; Stephen G Grant
Journal:  Exp Cell Res       Date:  2003-11-15       Impact factor: 3.905

6.  Spontaneously arising red cells with a McLeod-like phenotype in normal donors.

Authors:  David J Araten; Katie J Sanders; Jeffrey Pu; Soohee Lee
Journal:  Mutat Res       Date:  2009-04-02       Impact factor: 2.433

7.  Age-associated decreases in human DNA repair capacity: Implications for the skin.

Authors:  I M Hadshiew; M S Eller; B A Gilchrest
Journal:  Age (Omaha)       Date:  1999-04

8.  Frequency of 6-thioguanine-resistant T cells is inversely related to the declining T-cell activities in aging mice.

Authors:  T Inamizu; N Kinohara; M P Chang; T Makinodan
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

9.  A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

Authors:  G A Cortopassi; D Shibata; N W Soong; N Arnheim
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

Review 10.  In vivo mutations in human blood cells: biomarkers for molecular epidemiology.

Authors:  R J Albertini; J A Nicklas; J C Fuscoe; T R Skopek; R F Branda; J P O'Neill
Journal:  Environ Health Perspect       Date:  1993-03       Impact factor: 9.031
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