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Literature DB >> 6492263

Effects of lysosomotropic weak bases on infection of BHK-21 cells by Sindbis virus.

Abstract

The effects of the lysosomotropic weak bases chloroquine, ammonium chloride, and amantadine as well as dansylcadaverine (an inhibitor of receptor mediated endocytosis) on the replication of Sindbis virus in tissue-cultured cells was examined. Chloroquine had no effect on the expression of virus-induced homologous interference. None of these drugs significantly affected the ability of a complex of a cell and single virion to form an infectious center. Chloroquine and ammonium chloride were found to inhibit the synthesis of virus RNA in established infections when added early in infection. These drugs also inhibited the production of progeny virions when added any time after infection. These results suggest that the antiviral activity of these agents may not be due to an ability to prevent transport of the virus genome into the cell cytoplasm.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1984 PMID： 6492263 PMCID： PMC254606

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

33 in total

1. Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

Authors: S Ohkuma; B Poole
Journal: Proc Natl Acad Sci U S A Date: 1978-07 Impact factor: 11.205

2. Envelopments of Sindbis virus: synthesis and organization of proteins in cells infected with wild type and maturation-defective mutants.

Authors: J F Smith; D T Brown
Journal: J Virol Date: 1977-06 Impact factor: 5.103

3. Rapid acidification of endocytic vesicles containing alpha 2-macroglobulin.

Authors: B Tycko; F R Maxfield
Journal: Cell Date: 1982-03 Impact factor: 41.582

Review 4. Review article initial stages in infection with animal viruses.

Authors: N J Dimmock
Journal: J Gen Virol Date: 1982-03 Impact factor: 3.891

5. Inhibitors of lysosomal function.

Authors: P O Seglen
Journal: Methods Enzymol Date: 1983 Impact factor: 1.600

6. Specific Sindbis virus-coded function for minus-strand RNA synthesis.

Authors: D L Sawicki; S G Sawicki; S Keränen; L Kääriäinen
Journal: J Virol Date: 1981-08 Impact factor: 5.103

7. Morphology of BHK-21 Cells Infected with Sindbis Virus Temperature-Sensitive Mutants in Complementation Groups D and E.

Authors: D T Brown; J F Smith
Journal: J Virol Date: 1975-05 Impact factor: 5.103

5. BHK cells expressing Sindbis virus-induced homologous interference allow the translation of nonstructural genes of superinfecting virus.

Authors: R H Adams; D T Brown
Journal: J Virol Date: 1985-05 Impact factor: 5.103

6. The proteolytic cleavage of PE2 to envelope glycoprotein E2 is not strictly required for the maturation of Sindbis virus.

Authors: J F Presely; D T Brown
Journal: J Virol Date: 1989-05 Impact factor: 5.103

Effects of lysosomotropic weak bases on infection of BHK-21 cells by Sindbis virus.

1. Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

2. Envelopments of Sindbis virus: synthesis and organization of proteins in cells infected with wild type and maturation-defective mutants.

3. Rapid acidification of endocytic vesicles containing alpha 2-macroglobulin.

Review 4. Review article initial stages in infection with animal viruses.

5. Inhibitors of lysosomal function.

6. Specific Sindbis virus-coded function for minus-strand RNA synthesis.

7. Morphology of BHK-21 Cells Infected with Sindbis Virus Temperature-Sensitive Mutants in Complementation Groups D and E.

8. Inhibition of Semliki forest virus penetration by lysosomotropic weak bases.

9. Effects of chloroquine and cytochalasin B on the infection of cells by Sindbis virus and vesicular stomatitis virus.

10. Isolation and properties of the plasma membrane of KB cells.

1. Low-pH-dependent fusion of Sindbis virus with receptor-free cholesterol- and sphingolipid-containing liposomes.

2. Kinetics of poliovirus uncoating in HeLa cells in a nonacidic environment.

3. Alphavirus genome delivery occurs directly at the plasma membrane in a time- and temperature-dependent process.

4. Fusion of Semliki Forest virus infected Aedes albopictus cells at low pH is a fusion from within.

5. BHK cells expressing Sindbis virus-induced homologous interference allow the translation of nonstructural genes of superinfecting virus.

6. The proteolytic cleavage of PE2 to envelope glycoprotein E2 is not strictly required for the maturation of Sindbis virus.

Review 7. The alphaviruses: gene expression, replication, and evolution.

8. Entry of Rice dwarf virus into cultured cells of its insect vector involves clathrin-mediated endocytosis.

9. The clathrin endocytic pathway in viral infection.

10. Exposure to low pH is not required for penetration of mosquito cells by Sindbis virus.