Literature DB >> 6492258

Adenovirus 12 nononcogenic mutants: oncogenicity of transformed cells and viral proteins synthesized in vivo and in vitro.

I Mak, H Galet, S Mak.   

Abstract

Several nononcogenic cyt mutants of adenovirus type 12 induced the same E1A (55,000 [55K] and 25K) and E1B polypeptides (55K, 19K, and 17K) as did the wild-type virus, except that cyt 68 did not induce the E1B 19K protein. Tumorigenicity tests showed cells transformed by cyt 68 to be highly oncogenic in vivo. Therefore, it was concluded that the E1B 19K polypeptide is not necessary for tumor induction but may be involved in the efficiency of transformation.

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Year:  1984        PMID： 6492258      PMCID： PMC254575     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  17 in total

1.  Transformation of a rat cell line by an adenovirus type 12 DNA fragment.

Authors:  S Yano; S Ojima; K Fujinaga; K Shiroki; H Shimojo
Journal:  Virology       Date:  1977-10-01       Impact factor: 3.616

2.  Establishment and characterization of rat cell lines transformed by restriction endonuclease fragments of adenovirus 12 DNA.

Authors:  K Shiroki; H Handa; H Shimojo; S Yano; S Ojima; K Fujinaga
Journal:  Virology       Date:  1977-10-15       Impact factor: 3.616

3.  Purification and mapping of specific mRNAs by hybridization-selection and cell-free translation.

Authors:  R P Ricciardi; J S Miller; B E Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

4.  Incomplete transformation of rat cells by a small fragment of adenovirus 12 DNA.

Authors:  K Shiroki; H Shimojo; Y Sawada; Y Uemizu; K Fujinaga
Journal:  Virology       Date:  1979-05       Impact factor: 3.616

5.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

6.  Genetic studies with tumorigenic adenoviruses. I. Isolation of cytocidal (cyt) mutants of adenovirus type 12.

Authors:  N Takemori; J L Riggs; C Aldrich
Journal:  Virology       Date:  1968-12       Impact factor: 3.616

7.  In vitro translation of adenovirus type 12-specific mRNA complementary to the transforming gene.

Authors:  K Segawa; I Saito; K Shiroki; H Shimojo
Journal:  Virology       Date:  1980-11       Impact factor: 3.616

8.  Tumorigenicity and viral gene expression in rat cells transformed by Ad 12 virions or by the EcoRI c fragment of Ad 12 DNA.

Authors:  S Mak; I Mak; J R Smiley; F L Graham
Journal:  Virology       Date:  1979-10-30       Impact factor: 3.616

9.  Expression of early viral gene products in adenovirus type 12-infected and -transformed cells.

Authors:  H Esche; B Siegmann
Journal:  J Gen Virol       Date:  1982-05       Impact factor: 3.891

10.  Expression of early adenovirus genes requires a viral encoded acidic polypeptide.

Authors:  R P Ricciardi; R L Jones; C L Cepko; P A Sharp; B E Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205
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  2 in total

1.  Overexpression of the E1B 55-kilodalton (482R) protein of human adenovirus type 12 appears to permit efficient transformation of primary baby rat kidney cells in the absence of the E1B 19-kilodalton protein.

Authors:  S Zhang; S Mak; P E Branton
Journal:  J Virol       Date:  1992-04       Impact factor: 5.103

2.  The adenovirus type 12 early-region 1B 58,000-Mr gene product is required for viral DNA synthesis and for initiation of cell transformation.

Authors:  K Shiroki; K Ohshima; Y Fukui; H Ariga
Journal:  J Virol       Date:  1986-03       Impact factor: 5.103
  2 in total

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