Literature DB >> 6491928

Synthesis and biological evaluation of new 2,3-dihydrothiazole derivatives for antimicrobial, antihypertensive, and anticonvulsant activities.

A M Omar, N H Eshba.   

Abstract

A novel series of 2-arylimino-2,3-dihydrothiazole derivatives, substituted in the 3-position with a beta-phenethyl moiety and the 4-position with substituted aryl functions, was synthesized as potential antimicrobial, antihypertensive and anticonvulsive agents. While no antimicrobial or significant antihypertensive activity was observed for the products, XII, XIII, and XXI displayed potent anticonvulsant activity.

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Year:  1984        PMID: 6491928     DOI: 10.1002/jps.2600730837

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN: 0022-3549            Impact factor:   3.534


  3 in total

1.  Synthesis and Molecular Docking Study of New Thiazole Derivatives as Potential Tubulin Polymerization Inhibitors.

Authors:  Azhar O El-Abd; Said M Bayomi; Ashraf K El-Damasy; Basem Mansour; Naglaa I Abdel-Aziz; Magda A El-Sherbeny
Journal:  ACS Omega       Date:  2022-09-07

2.  Exploring 2-Tetradecanoylimino-3-aryl-4-methyl-1,3-thiazolines Derivatives as Alkaline Phosphatase Inhibitors: Biochemical Evaluation and Computational Analysis.

Authors:  Aftab Ahmed; Sajid-Ur Rehman; Syeda Abida Ejaz; Aamer Saeed; Rabail Ujan; Pervaiz Ali Channar; Khalida Mahar; Reshma Sahito; Sarah M Albogami; Qamar Abbas; Mohammed Alorabi; Michel De Waard; Gaber El-Saber Batiha
Journal:  Molecules       Date:  2022-10-10       Impact factor: 4.927

3.  Design, facile synthesis and anthelmintic activity of new O-substituted 6-methoxybenzothiazole-2-carbamates. Part II.

Authors:  A Mohsen M E Omar; Omaima M Aboulwafa; Doaa A E Issa; Mai S M El-Shoukrofy; May E Amr; Ibrahim M El-Ashmawy
Journal:  Medchemcomm       Date:  2017-05-12       Impact factor: 3.597

  3 in total

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