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Literature DB >> 649168

Cytogenetic study in spermatocytes of mice and Chinese hamsters after treatment with isoniazid (INH).

I D Adler, A Schmaltz, R Rathenberg, D Müller, F F Strasser, R Perret.

Abstract

Meiotic chromosomes of spermatocytes from INH-treated male mice and Chinese hamsters were analysed for chromosome aberrations in diakinesis-metaphase I and metaphase II. The experiments were performed in two laboratories while a third laboratory participated in the chromosome evaluation. No enhancement of chromosome aberrations could be observed after acute treatment of early primary spermatocytes or chronic treatment of spermatogonia with INH.

Entities: Chemical Species

Mesh：

Substances：
Isoniazid

Year: 1978 PMID： 649168 DOI： 10.1007/BF00291623

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

8 in total

1. 6-mercaptopurine, an inducer of cytogenetic and dominant-lethal effects in premeiotic and early meiotic germ cells of male mice.

Authors: W M Generoso; R J Preston; J G Brewen
Journal: Mutat Res Date: 1975-06 Impact factor: 2.433

7. [On the effects of trenimon and endoxan on meiosis in male mice. I. Method of preparation and analysis of meiotic divisions].

Authors: E Schleiermacher
Journal: Humangenetik Date: 1966

8. Comparative cytogenetic studies of the influence of phenylbutazone and cyclophosphamide on spermatogenesis in the mouse.

Authors: R Rathenberg; D Müller
Journal: Agents Actions Date: 1972-06

8 in total

4 in total

1. Incidence of chromosomal aberrations in patients under combined tuberculostatic chemotherapy.

Authors: I C Roman; E Vainer; I Socosan; T Drăghicescu
Journal: Hum Genet Date: 1983 Impact factor: 4.132

2. Chromosome-damaging action of isoniazid and thiacetazone on human lymphocyte cultures in vivo.

Authors: Y R Ahuja; M Jaju; M Jaju
Journal: Hum Genet Date: 1981 Impact factor: 4.132

3. Cytogenetic effects of chemotherapy with three combinations of anti-tubercular drugs involving isoniazid, thiacetazone, para-aminosalicylic acid and streptomycin on human lymphocytes: chromosome aberrations, sister chromatid exchanges and mitotic index.

Authors: M Jaju; M Jaju; Y R Ahuja
Journal: Hum Genet Date: 1983 Impact factor: 4.132

4. Combined action of isoniazid and para-aminosalicylic acid in vivo on human chromosomes in lymphocyte cultures.

Authors: M Jaju; M Jaju; Y R Ahuja
Journal: Hum Genet Date: 1981 Impact factor: 4.132

4 in total

Cytogenetic study in spermatocytes of mice and Chinese hamsters after treatment with isoniazid (INH).

1. 6-mercaptopurine, an inducer of cytogenetic and dominant-lethal effects in premeiotic and early meiotic germ cells of male mice.

2. AN AIR-DRYING METHOD FOR MEIOTIC PREPARATIONS FROM MAMMALIAN TESTES.

3. Observation of dividing spermatocytes for chromosome aberrations induced in mouse spermatogonia by chemical mutagens.

4. Comparative cytogenetic study after treatment of mouse spermatogonia with mitomycin C.

5. Initial chromosomal lesions induced by x-irradiating primary spermatocytes of mice.