Literature DB >> 649164

Mutagenicity of isoniazid: testing for somatic chromosome aberrations in mouse embryos.

J Fränz.   

Abstract

Isonicotinic acid hydrazide (INH) were given by peroral intubation to pregnant mice of strain C57BL/6Ffm on day 9 of pregnancy, INH was given in the following doses: 0, 5, 25, and 125 mg/kg solved in physiological saline. Cytogenetic analysis of homogenized embryos 6, 12, 24, and 48 h, resp., after treatment of the females did not show any increase of the rate of gaps or chromosomal aberrations.

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Year:  1978        PMID： 649164     DOI： 10.1007/BF00291620

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  2 in total

1.  CHROMOSOME CHANGES IN RAT EMBRYOS FOLLOWING X-IRRADIATION.

Authors:  S W SOUKUP; E TAKACS; J WARKANY
Journal:  Cytogenetics       Date:  1965

2.  Chromosomal breakage and teratogenesis.

Authors:  C Roux; I Emerit; J L Taillemite
Journal:  Teratology       Date:  1971-08
  2 in total
  3 in total

1.  Chromosome-damaging action of isoniazid and thiacetazone on human lymphocyte cultures in vivo.

Authors:  Y R Ahuja; M Jaju; M Jaju
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

2.  Cytogenetic effects of chemotherapy with three combinations of anti-tubercular drugs involving isoniazid, thiacetazone, para-aminosalicylic acid and streptomycin on human lymphocytes: chromosome aberrations, sister chromatid exchanges and mitotic index.

Authors:  M Jaju; M Jaju; Y R Ahuja
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

3.  Combined action of isoniazid and para-aminosalicylic acid in vivo on human chromosomes in lymphocyte cultures.

Authors:  M Jaju; M Jaju; Y R Ahuja
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132
  3 in total

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