Literature DB >> 6488472

A methodology for the analysis of the preneoplastic antigen.

B D Hammock, D N Loury, D E Moody, B Ruebner, R Baselt, K M Milam, P Volberding, A Ketterman, R Talcott.   

Abstract

A highly sensitive assay for the epoxide hydrolase activity associated with the preneoplastic antigen (PNA) has been developed based on the synthesis of cis-stilbene oxide labeled with tritium at approximately 15 Ci/mmol. This assay allows the detection of elevated epoxide hydrolase activity in the serum of humans and rodents as well as in the culture medium bathing isolated hepatocytes. The integrity of the enzymatic assay was confirmed in rodents by precipitating the serum PNA activity using an antibody raised against the rat microsomal epoxide hydrolase. Methodology for the detection of PNA in serum will facilitate evaluation of this antigen as a marker for hepatic neoplasia in man and in experimental animals.

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Year:  1984        PMID： 6488472     DOI： 10.1093/carcin/5.11.1467

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  7 in total

Review 1.  Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indications.

Authors:  Hong C Shen; Bruce D Hammock
Journal:  J Med Chem       Date:  2012-01-17       Impact factor: 7.446

2.  Monoclonal antibodies reveal multiple forms of expression of human microsomal epoxide hydrolase.

Authors:  Hongying Duan; Akira Takagi; Hidekazu Kayano; Isamu Koyama; Christophe Morisseau; Bruce D Hammock; Toshitaka Akatsuka
Journal:  Toxicol Appl Pharmacol       Date:  2012-01-28       Impact factor: 4.219

3.  Development of monoclonal antibodies to human microsomal epoxide hydrolase and analysis of "preneoplastic antigen"-like molecules.

Authors:  Hongying Duan; Kazunori Yoshimura; Nobuharu Kobayashi; Kazuo Sugiyama; Jun-Ichi Sawada; Yoshiro Saito; Christophe Morisseau; Bruce D Hammock; Toshitaka Akatsuka
Journal:  Toxicol Appl Pharmacol       Date:  2012-01-28       Impact factor: 4.219

4.  Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys.

Authors:  A Ulu; Se Appt; C Morisseau; S H Hwang; P D Jones; T E Rose; H Dong; J Lango; J Yang; H J Tsai; C Miyabe; C Fortenbach; M R Adams; B D Hammock
Journal:  Br J Pharmacol       Date:  2012-03       Impact factor: 8.739

5.  Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A.

Authors:  Toshitaka Akatsuka; Nobuharu Kobayashi; Takashi Ishikawa; Takafumi Saito; Michiko Shindo; Masayoshi Yamauchi; Kazutaka Kurokohchi; Hitoshi Miyazawa; Hongying Duan; Toshiyuki Matsunaga; Tsugikazu Komoda; Christophe Morisseau; Bruce D Hammock
Journal:  J Autoimmun       Date:  2007-02-12       Impact factor: 7.094

6.  Development of potent inhibitors of the human microsomal epoxide hydrolase.

Authors:  Bogdan Barnych; Nalin Singh; Sophie Negrel; Yue Zhang; Damien Magis; Capucine Roux; Xiude Hua; Zhewen Ding; Christophe Morisseau; Dean J Tantillo; Justin B Siegel; Bruce D Hammock
Journal:  Eur J Med Chem       Date:  2020-03-13       Impact factor: 6.514

Review 7.  Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration.

Authors:  Morteza Sarparast; Devon Dattmore; Jamie Alan; Kin Sing Stephen Lee
Journal:  Nutrients       Date:  2020-11-16       Impact factor: 5.717
  7 in total

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