| Literature DB >> 6488145 |
R M Silgals, J D Ahlgren, J R Neefe, J Rothman, S Rudnick, F P Galicky, P S Schein.
Abstract
Twenty-one patients with metastatic colorectal cancer were treated with high-dose intravenous interferon alpha-2 (30-50 X 10(6) units/m2) administered daily for 5 consecutive days. Courses of therapy were repeated every 2 to 3 weeks. No tumor responses were seen among 15 evaluable patients. In two subjects, disease remained stable for 3 and 7 months, respectively. Toxicity was substantial and a de-escalation of dose was frequently required. Fevers, gastrointestinal symptoms, fatigue, leukopenia, and elevated serum transaminases were common. High-dose interferon was found to be ineffective in the treatment of metastatic colorectal cancer. A daily dose of 50 X 10(6) units/m2 was greater than the maximum tolerated dose in this group of patients.Entities:
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Year: 1984 PMID： 6488145 DOI： 10.1002/1097-0142(19841115)54:10<2257::aid-cncr2820541032>3.0.co;2-c
Source DB: PubMed Journal: Cancer ISSN： 0008-543X Impact factor: 6.860