Literature DB >> 6487986

Treatment of uncomplicated gonorrhoea in women with a combination of rifampicin and erythromycin.

A J Boakes, P S Loo, G L Ridgway, S Tovey, J D Oriel.   

Abstract

One hundred women with uncomplicated gonorrhoea (in five cases due to penicillinase producing strains of Neisseria gonorrhoeae (PPNG)) were treated with a single oral dose of rifampicin 900 mg and erythromycin stearate 1 g. N gonorrhoeae was reisolated from the oropharynx of one patient, who was infected with a PPNG strain, but was eradicated from the genital tract in 100% of cases. The combination eradicated Chlamydia trachomatis from only 10 (28%) of the 36 patients infected. Side effects were predominantly mild and consisted of transient nausea. The treatment merits evaluation in areas with a high incidence of PPNG strains.

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Year:  1984        PMID： 6487986      PMCID： PMC1046345          DOI： 10.1136/sti.60.5.309

Source DB:  PubMed          Journal:  Br J Vener Dis        ISSN： 0007-134X


  9 in total

1.  Penicillinase-producing Neisseria gonorrhoeae.

Authors: 
Journal:  Lancet       Date:  1976-10-09       Impact factor: 79.321

2.  Penicillinase-producing Neisseria gonorrhoeae in Great Britain, 1977-81: alarming increase in incidence and recent development of endemic transmission.

Authors:  J A McCutchan; M W Adler; J R Berrie
Journal:  Br Med J (Clin Res Ed)       Date:  1982-07-31

3.  Evidence that rifampicin can be used safely for non-tuberculous diseases.

Authors:  G Acocella; W Brumfitt; J M Hamilton-Miller
Journal:  Thorax       Date:  1980-10       Impact factor: 9.139

4.  Penicillinase-producing Neisseria gonorrhoeae.

Authors:  T J McManus; J R Harris; C A Ison; C S Easmon
Journal:  N Engl J Med       Date:  1982-12-30       Impact factor: 91.245

5.  Rifampicin compared with penicllin in the treatment of gonorrhea.

Authors:  A S Malmborg; L Molin; B Nyström
Journal:  Chemotherapy       Date:  1971       Impact factor: 2.544

6.  Comparison of erythromycin stearate and oxytetracycline in the treatment of non-gonococcal urethritis: their efficacy against Chlamydia trachomatis.

Authors:  J D Oriel; G L Ridgway; S Tchamouroff
Journal:  Scott Med J       Date:  1977-12       Impact factor: 0.729

7.  Treatment of gonococcal urethritis in men with a rifampicin-erythromycin combination.

Authors:  J D Oriel; G L Ridgway; D Goldmeier; D Felmingham
Journal:  Sex Transm Dis       Date:  1982 Oct-Dec       Impact factor: 2.830

8.  Treatment of gonorrhoea with single oral doses of rifampicin.

Authors:  R J Cobbold; G D Morrison; R R Willcox
Journal:  Br Med J       Date:  1968-12-14

9.  Comparison of erythromycin base and estolate in gonococcal urethritis.

Authors:  S T Brown; H B Pedersen; K K Holmes
Journal:  JAMA       Date:  1977-09-26       Impact factor: 56.272
  9 in total
  4 in total

1.  In vitro synergy testing of novel antimicrobial combination therapies against Neisseria gonorrhoeae.

Authors:  Lindley A Barbee; Olusegun O Soge; King K Holmes; Matthew R Golden
Journal:  J Antimicrob Chemother       Date:  2014-01-26       Impact factor: 5.790

Review 2.  Use of rifampin in nonstaphylococcal, nonmycobacterial disease.

Authors:  A B Morris; R B Brown; M Sands
Journal:  Antimicrob Agents Chemother       Date:  1993-01       Impact factor: 5.191

Review 3.  Antimicrobial susceptibility testing of Neisseria gonorrhoeae and implications for epidemiology and therapy.

Authors:  T Fekete
Journal:  Clin Microbiol Rev       Date:  1993-01       Impact factor: 26.132

4.  Rifampicin Resistance Associated with rpoB Mutations in Neisseria gonorrhoeae Clinical Strains Isolated in Austria, 2016 to 2020.

Authors:  Justine Schaeffer; Kathrin Lippert; Sonja Pleininger; Anna Stöger; Petra Hasenberger; Silke Stadlbauer; Florian Heger; Angelika Eigentler; Alexandra Geusau; Alexander Indra; Franz Allerberger; Werner Ruppitsch
Journal:  Microbiol Spectr       Date:  2022-06-09
  4 in total

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