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Literature DB >> 6487737

Effect of colchicine on viscoelastic properties of neutrophils.

Abstract

The effect of colchicine (15-60 micrograms/ml) on the viscoelastic properties of human neutrophils was studied by the micropipette technique. The small deformation of the neutrophil in response to a step aspiration pressure was analyzed by using a three-element model in which an elastic element, K1, is in parallel with a Maxwell element composed of another elastic element, K2, in series with a viscous element, mu. Colchicine treatment of neutrophils caused decreases in K2 and mu without affecting K1. The results indicate that the integrity of the microtubules plays a significant role in providing the viscoelastic resistance (as represented by the Maxwell element in the model) of neutrophils to deforming stress.

Entities: Chemical Species

Mesh：

Substances：
Colchicine
Calcium

Year: 1984 PMID： 6487737 PMCID： PMC1434951 DOI： 10.1016/S0006-3495(84)84034-5

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

11 in total

1. Cellular deformability of the human peripheral blood polymorphonuclear leukocyte: method of study, normal variation and effects of physical and chemical alterations.

Authors: M E Miller; K Myers
Journal: J Reticuloendothel Soc Date: 1975-12

2. Myosin in polymorphonuclear leukocytes.

Authors: T P Stossel; T D Pollard
Journal: J Biol Chem Date: 1973-12-10 Impact factor: 5.157

Review 3. The role of membrane-associated enzymes in regulation of erythrocyte shape and deformability.

Authors: N Mohandas; S B Shohet
Journal: Clin Haematol Date: 1981-02

4. Morphometry of human leukocytes.

Authors: G W Schmid-Schönbein; Y Y Shih; S Chien
Journal: Blood Date: 1980-11 Impact factor: 22.113

5. Passive mechanical properties of human leukocytes.

Authors: G W Schmid-Schönbein; K L Sung; H Tözeren; R Skalak; S Chien
Journal: Biophys J Date: 1981-10 Impact factor: 4.033

6. Influence of physicochemical factors on rheology of human neutrophils.

Authors: K L Sung; G W Schmid-Schönbein; R Skalak; G B Schuessler; S Usami; S Chien
Journal: Biophys J Date: 1982-07 Impact factor: 4.033

7. Intermediate filaments as mechanical integrators of cellular space.

Authors: E Lazarides
Journal: Nature Date: 1980-01-17 Impact factor: 49.962

8. Rheology of leukocytes, leukocyte suspensions, and blood in leukemia. Possible relationship to clinical manifestations.

Authors: M A Lichtman
Journal: J Clin Invest Date: 1973-02 Impact factor: 14.808

9. Correlation of the biologic effects and binding of cytochalasins to human polymorphonuclear leukocytes.

Authors: T H Howard; J Casella; S Lin
Journal: Blood Date: 1981-03 Impact factor: 22.113

10. Actin, alpha-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells.

Authors: E Lazarides
Journal: J Cell Biol Date: 1976-02 Impact factor: 10.539

11 in total

Effect of colchicine on viscoelastic properties of neutrophils.

1. Cellular deformability of the human peripheral blood polymorphonuclear leukocyte: method of study, normal variation and effects of physical and chemical alterations.

2. Myosin in polymorphonuclear leukocytes.

Review 3. The role of membrane-associated enzymes in regulation of erythrocyte shape and deformability.

4. Morphometry of human leukocytes.

5. Passive mechanical properties of human leukocytes.

6. Influence of physicochemical factors on rheology of human neutrophils.

7. Intermediate filaments as mechanical integrators of cellular space.

8. Rheology of leukocytes, leukocyte suspensions, and blood in leukemia. Possible relationship to clinical manifestations.

9. Correlation of the biologic effects and binding of cytochalasins to human polymorphonuclear leukocytes.

10. Actin, alpha-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells.

Review 1. Leukocyte biophysics. An invited review.

2. Characterization of cellular elastic modulus using structure based double layer model.

3. On-chip surface acoustic wave and micropipette aspiration techniques to assess cell elastic properties.

4. Passive mechanical behavior of human neutrophils: power-law fluid.

5. Viscosity of passive human neutrophils undergoing small deformations.

6. Passive mechanical behavior of human neutrophils: effect of cytochalasin B.

7. Mechanical properties of hepatocellular carcinoma cells.

8. Effect of cytochalasin D on the mechanical properties and morphology of passive human neutrophils.

9. Transient neutropenia after intravenous injection of vindesine in patients with lung cancer.

10. Passive mechanical behavior of human neutrophils: effects of colchicine and paclitaxel.