| Literature DB >> 6487463 |
J O Miners, R A Robson, D J Birkett.
Abstract
The disposition of clofibric acid, a drug metabolised largely by glucuronidation, was studied in eight males, eight females and eight females receiving oral contraceptive steroids (OCS). Clofibric acid plasma clearance was not significantly different in males compared to the control female group but was 48% greater (P less than 0.01) in women receiving OCS compared to non-pill using females. This difference was due to an alteration in clofibric acid metabolic clearance as there were no differences between the groups in clofibric acid free fraction. Along with previous data the results suggest that induction of drug glucuronidation by OCS may be of clinical importance, although any sex-related differences are unlikely to be of clinical significance.Entities:
Keywords: Contraception; Contraceptive Agents; Contraceptive Agents, Female; Contraceptive Methods--pharmacodynamics; Drugs--men; Drugs--women; Ethinyl Estradiol; Examinations And Diagnoses; Family Planning; Hormones; Laboratory Examinations And Diagnoses; Laboratory Procedures; Levonorgestrel; Mestranol; Metabolic Effects; Norethynodrel; Oral Contraceptives--pharmacodynamics; Reproductive Control Agents; Treatment
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Year: 1984 PMID： 6487463 PMCID： PMC1463532 DOI： 10.1111/j.1365-2125.1984.tb02461.x
Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335