Repair of the mouse synovial membrane after chemical synovectomy with osmium tetroxide.

Repair of the synovium of the mouse knee joint following intra-articular injection with osmium tetroxide has been studied by light and electron microscopy. Within a first few days after osmium tetroxide injection complete necrosis of the synovial intima and inflammatory response in the subintimal connective tissue occurred. The resurfacing of the denuded synovium was performed by proliferation of immature synovioblasts which appeared to be derived from mesenchymal cells in the transition zone. The synovial intima completely restored the original structure, while repair of the subintimal tissue was accomplished by a scarring.