[Perioperative antibiotic therapy--clinical experiences with a combination of mezlocillin/sisomicin in accident surgery].

The clinical and bacteriological efficiency of the combination Mezlocillin and Sisomicin was studied in 25 patients from the Department of trauma. In 9 cases the combination of antibiotics was used for treatment of manifest infections. 16 patients received a prophylaxis before and after operation. Among them were patients with open fractures, with a large soft tissue damage, polytraumatized patients with multiple injuries or patients with pathological fractures. Dosage of Mezlocillin was 4 g every 8 h, and dosage of Sisomicin was 75 mg every 8 h. Mean duration of therapy was 6 days. In 24 cases the combination of antibiotics was successful. In one case occurred a postoperative haematoma without bacterial findings. In all infections (9 cases) isolated germs were achieved with the combination Mezlocillin and Sisomicin.