Literature DB >> 6484448

Distribution of [3H]-D-penicillamine in mouse kidney. An autoradiographic study.

E de Angelis, M L Lombardi, V Ruocco.   

Abstract

3H-labeled D-penicillamine has been injected in mice in order to study by autoradiography its distribution in the kidney. The results show heavy accumulation of the drug in the epithelial cells of the proximal tubules of the kidney, whereas glomeruli and distal tubules do not show any significant accumulation. This peculiar tropism of penicillamine to proximal tubules is entirely consistent with the Heymann's nephritis model suggested by Bacon as a pathogenetic model for penicillamine-induced nephropathy.

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Year:  1984        PMID： 6484448     DOI： 10.1007/bf00541212

Source DB:  PubMed          Journal:  Rheumatol Int        ISSN： 0172-8172            Impact factor:   2.631


  25 in total

1.  Membranous nephropathy due to skin-lightening cream.

Authors:  J W Kibukamusoke; D R Davies; M S Hutt
Journal:  Br Med J       Date:  1974-06-22

2.  Penicillamine pemphigus and the nephrotic syndrome occurring simultaneously.

Authors:  G P Sparrow
Journal:  Br J Dermatol       Date:  1978-01       Impact factor: 9.302

3.  Early events of the host-tumor interaction, local tissue reactions in tumor take, growth, and metastasis.

Authors:  E de Angelis; G G Giordano; A Orengo
Journal:  Cell Mol Biol Incl Cyto Enzymol       Date:  1980

4.  An abortive form of pemphigus vulgaris probably induced by penicillin.

Authors:  V Ruocco; A Rossi; M Pisani; C Astarita; L Alviggi
Journal:  Dermatologica       Date:  1979

5.  Penicillamine in rheumatoid arthritis: clinical pharmacology and biochemical properties.

Authors:  I A Jaffe
Journal:  Scand J Rheumatol Suppl       Date:  1979

6.  Association of the B-cell alloantigen DRw4 with rheumatoid arthritis.

Authors:  P Stastny
Journal:  N Engl J Med       Date:  1978-04-20       Impact factor: 91.245

7.  Specific incorporation of penicillamine into the epidermis of mice: an autoradiographic study.

Authors:  V Ruocco; E De Angelis; M De Luca; M Pisani; G Prota
Journal:  Br J Dermatol       Date:  1983-04       Impact factor: 9.302

8.  Genetic basis of rheumatoid disease: HLA antigens, disease manifestations, and toxic reactions to drugs.

Authors:  G S Panayi; P Wooley; J R Batchelor
Journal:  Br Med J       Date:  1978-11-11

9.  Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions.

Authors:  W HEYMANN; D B HACKEL; S HARWOOD; S G WILSON; J L HUNTER
Journal:  Proc Soc Exp Biol Med       Date:  1959-04

10.  HLA-DR antigens and toxic reaction to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis.

Authors:  P H Wooley; J Griffin; G S Panayi; J R Batchelor; K I Welsh; T J Gibson
Journal:  N Engl J Med       Date:  1980-08-07       Impact factor: 91.245
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