| Literature DB >> 6482646 |
M Waelbroeck, P De Neef, P Robberecht, J Christophe.
Abstract
Quinidine inhibited binding of the labelled agonist [3H]oxotremorine M [( 3H]Oxo-M) and the labelled antagonist [3H]N-methylscopolamine [( 3H]NMS) to rat heart muscarinic receptors. Kinetic studies demonstrated that quinidine decreased the association rates (I50: 4 and 7.5 microM) and dissociation rates (I50: 100 and 68 microM) of [3H]Oxo-M and [3H]NMS, with different potencies. These cooperative effects explained the low Hill coefficients and apparent selectivity of quinidine competition curves.Entities:
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Year: 1984 PMID： 6482646 DOI： 10.1016/0024-3205(84)90071-7
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037