Literature DB >> 6481179

Interaction of brown recluse spider venom on cell membranes: the inciting mechanism?

R S Rees, L B Nanney, R A Yates, L E King.   

Abstract

The venom from the brown recluse spider, Loxosceles reclusa, contains one or more factors which produce skin necrosis. A dermonecrotic factor with sphingomyelinase D activity was purified from the spider's venom sacs which produced skin necrosis when injected intradermally in rabbits. Adsorption of the dermonecrotic activity occurred following incubation with isolated membranes from different cell types or different species in a dose-responsive fashion. Since injection of the complex in rabbits produced skin necrosis, a specific antibody that inhibits the dermonecrotic activity and sphingomyelinase activity was used to identify the venom fraction on the plasma membrane of erythrocytes with electron microscopy. Initiation of cutaneous inflammatory reaction may result from high-affinity interaction of a venom component in the brown recluse spider venom and cell membranes.

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Year:  1984        PMID： 6481179     DOI： 10.1111/1523-1747.ep12340340

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  7 in total

1.  Loxosceles spider venom induces the production of alpha and beta chemokines: implications for the pathogenesis of dermonecrotic arachnidism.

Authors:  H F Gomez; M J Miller; A Desai; J S Warren
Journal:  Inflammation       Date:  1999-06       Impact factor: 4.092

2.  Inhibition of CFTR Cl- channel function caused by enzymatic hydrolysis of sphingomyelin.

Authors:  Yajamana Ramu; Yanping Xu; Zhe Lu
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-30       Impact factor: 11.205

3.  Effect of brown spider venom on basement membrane structures.

Authors:  S S Veiga; L Feitosa; V L dos Santos; G A de Souza; A S Ribeiro; O C Mangili; M A Porcionatto; H B Nader; C P Dietrich; R R Brentani; W Gremski
Journal:  Histochem J       Date:  2000-07

4.  Brown recluse spider bites. A comparison of early surgical excision versus dapsone and delayed surgical excision.

Authors:  R S Rees; D P Altenbern; J B Lynch; L E King
Journal:  Ann Surg       Date:  1985-11       Impact factor: 12.969

5.  Compared chemical properties of dermonecrotic and lethal toxins from spiders of the genus Loxosceles (Araneae).

Authors:  K C Barbaro; M V Sousa; L Morhy; V R Eickstedt; I Mota
Journal:  J Protein Chem       Date:  1996-05

6.  Venom of the Brazilian spider Sicarius ornatus (Araneae, Sicariidae) contains active sphingomyelinase D: potential for toxicity after envenomation.

Authors:  Priscila Hess Lopes; Rogério Bertani; Rute M Gonçalves-de-Andrade; Roberto H Nagahama; Carmen W van den Berg; Denise V Tambourgi
Journal:  PLoS Negl Trop Dis       Date:  2013-08-22

7.  Targeting Loxosceles spider Sphingomyelinase D with small-molecule inhibitors as a potential therapeutic approach for loxoscelism.

Authors:  Priscila Hess Lopes; Mário T Murakami; Fernanda C V Portaro; Kerly Fernanda Mesquita Pasqualoto; Carmen van den Berg; Denise V Tambourgi
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051
  7 in total

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