Literature DB >> 6478113

Angiotensin II does not inhibit vagally-induced bradycardia or gastric contractions in the anaesthetized ferret.

P L Andrews, M B Dutia, P J Harris.   

Abstract

The effects of angiotensin II (AII) and the analogue Sar1-Leu8-angiotensin II on the changes in heart rate and gastric pressure induced by vagal stimulation were investigated in the urethane-anaesthetized ferret. AII at high doses (500 ng kg-1 i.v.) increased blood pressure and decreased gastric pressure whereas Sar1-Leu8-AII at the same dose had a much smaller effect on blood pressure and no effect on gastric pressure. Intravenous injections or infusions of AII or its analogue did not alter the effect of vagal stimulation on heart rate or gastric motility. Our results do not provide support for the proposal that AII modulates parasympathetic activity at peripheral sites (Potter, 1982a, b).

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Year:  1984        PMID： 6478113      PMCID： PMC1986920          DOI： 10.1111/j.1476-5381.1984.tb16480.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  13 in total

Review 1.  Regulation of noradrenaline release by presynaptic receptor systems.

Authors:  K Starke
Journal:  Rev Physiol Biochem Pharmacol       Date:  1977       Impact factor: 5.545

2.  Interaction of angiotensin II with noradrenaline and other spasmogens on rabbit isolated aortic strips.

Authors:  M D Day; A F Moore
Journal:  Arch Int Pharmacodyn Ther       Date:  1976-01

Review 3.  Renin-angiotensin system: biochemistry and mechanisms of action.

Authors:  M J Peach
Journal:  Physiol Rev       Date:  1977-04       Impact factor: 37.312

4.  Angiotensin analogs: the influence of sarcosine substituted in position 1.

Authors:  M M Hall; M C Khosla; P A Khairallah; F M Bumpus
Journal:  J Pharmacol Exp Ther       Date:  1974-01       Impact factor: 4.030

5.  Effect of angiotensin on the response to norepinephrine and peri-arterial stimulation of the isolated perfused cat terminal ileum.

Authors:  R K Türker
Journal:  Eur J Pharmacol       Date:  1973-02       Impact factor: 4.432

6.  Effect of angiotensin and phenoxybenzamine on release of norepinephrine in vessels during sympathetic nerve stimulation.

Authors:  B G Zimmerman; L Whitmore
Journal:  Int J Neuropharmacol       Date:  1967-01

7.  Inhibitory effect of angiotensin on the intestinal motility of the cat and its relation to sympathetic nervous system.

Authors:  R K Türker; S O Kayaalp
Journal:  Arch Int Physiol Biochim       Date:  1967-12

8.  Peripheral functional organisation of vagally evoked gastric motor responses in the ferret.

Authors:  P L Andrews; I N Lawes; A J Bower
Journal:  Gut       Date:  1980-10       Impact factor: 23.059

9.  The gastric motility patterns induced by direct and reflex excitation of the vagus nerves in the anaesthetized ferret.

Authors:  P L Andrews; T Scratcherd
Journal:  J Physiol       Date:  1980-05       Impact factor: 5.182

10.  Some aspects of the physiology and anatomy of the cardiovascular system of the ferret, Mustela putorius furo.

Authors:  P L Andrews; A J Bower; O Illman
Journal:  Lab Anim       Date:  1979-07       Impact factor: 2.471
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  1 in total

1.  A facilitatory effect of anti-angiotensin drugs on vagal bradycardia in the pithed rat and guinea-pig.

Authors:  M Rechtman; H Majewski
Journal:  Br J Pharmacol       Date:  1993-09       Impact factor: 8.739
  1 in total

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