Literature DB >> 6477532

The fatty acid composition of phosphatidylinositol, phosphatidate and 1,2-diacylglycerol in stimulated human neutrophils.

S Cockcroft, D Allan.   

Abstract

The fatty acid composition of phosphatidylinositol (PtdIns), phosphatidate (PtdOH) and 1,2-diacylglycerol (DG) was determined in cytochalasin B-treated human neutrophils in the presence and in the absence of formylmethionyl-leucyl-phenylalanine. The compositions of PtdOH and DG in stimulated cells resemble closely that of PtdOH in control cells and are quite different from the composition of PtdIns. DG appears to be produced as a subsequent metabolite of PtdOH and not as an intermediate in the conversion of PtdIns into PtdOH. We conclude that PtdOH is produced directly from a small pool of newly synthesized PtdIns in stimulated neutrophils.

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Year:  1984        PMID： 6477532      PMCID： PMC1144211          DOI： 10.1042/bj2220557

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  15 in total

1.  Acetylcholine stimulation of selective increases in stearic and arachidonic acids in phosphatidic acid in mouse pancreas.

Authors:  R L Geison; M W Banschbach; K Sadeghian; M Hokin-Neaverson
Journal:  Biochem Biophys Res Commun       Date:  1976-01-26       Impact factor: 3.575

Review 2.  Metabolism of molecular species of diacylglycerophospholipids.

Authors:  B J Holub; A Kuksis
Journal:  Adv Lipid Res       Date:  1978

Review 3.  Inositol trisphosphate and diacylglycerol as second messengers.

Authors:  M J Berridge
Journal:  Biochem J       Date:  1984-06-01       Impact factor: 3.857

4.  Receptor-mediated activation of a phospholipase A2 in rabbit neutrophil plasma membrane.

Authors:  B J Bormann; C K Huang; W M Mackin; E L Becker
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

5.  The Ca2+-activated polyphosphoinositide phosphodiesterase of human and rabbit neutrophil membranes.

Authors:  S Cockcroft; J M Baldwin; D Allan
Journal:  Biochem J       Date:  1984-07-15       Impact factor: 3.857

6.  Use of cytochalasin B to distinguish between early and late events in neutrophil activation.

Authors:  J P Bennett; S Cockcroft; B D Gomperts
Journal:  Biochim Biophys Acta       Date:  1980-10-02

7.  Modification of positional distribution of fatty acids in phosphatidylinositol of rabbit neutrophils stimulated with formylmethionyl-leucyl-phenylalanine.

Authors:  K Yano; H Hattori; A Imai; Y Nozawa
Journal:  Biochim Biophys Acta       Date:  1983-06-16

8.  The fatty acid composition of 1,2-diacylglycerol and polyphosphoinositides from human erythrocyte membranes.

Authors:  D Allan; S Cockcroft
Journal:  Biochem J       Date:  1983-08-01       Impact factor: 3.857

9.  Mechanism of arachidonic acid release in human polymorphonuclear leukocytes.

Authors:  C E Walsh; L R Dechatelet; F H Chilton; R L Wykle; M Waite
Journal:  Biochim Biophys Acta       Date:  1983-01-07

10.  Role of Ca2+ in phosphatidylinositol response and arachidonic acid release in formylated tripeptide- or Ca2+ ionophore A23187-stimulated guinea pig neutrophils.

Authors:  T Takenawa; Y Homma; Y Nagai
Journal:  J Immunol       Date:  1983-06       Impact factor: 5.422
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  24 in total

1.  Involvement of PL-D in the alternate signal tranduction pathway of macrophages induced by an external stimulus.

Authors:  R Bandyopadhyay; M K Basu
Journal:  Mol Cell Biochem       Date:  2000-01       Impact factor: 3.396

Review 2.  The regulation and cellular functions of phosphatidylcholine hydrolysis.

Authors:  M M Billah; J C Anthes
Journal:  Biochem J       Date:  1990-07-15       Impact factor: 3.857

3.  Synergistic activation of phospholipase D by protein kinase C- and G-protein-mediated pathways in streptolysin O-permeabilized HL60 cells.

Authors:  B Geny; S Cockcroft
Journal:  Biochem J       Date:  1992-06-01       Impact factor: 3.857

Review 4.  The role of phosphoinositides in signal transduction.

Authors:  M C Sekar; L E Hokin
Journal:  J Membr Biol       Date:  1986       Impact factor: 1.843

Review 5.  The role of neutrophils in vascular injury: a summary of signal transduction mechanisms in cell/cell interactions.

Authors:  G Weissmann
Journal:  Springer Semin Immunopathol       Date:  1989

Review 6.  A short history of inositol lipids.

Authors:  Robin F Irvine
Journal:  J Lipid Res       Date:  2016-09-13       Impact factor: 5.922

7.  Resynthesis of phosphatidylinositol in permeabilized neutrophils following phospholipase Cbeta activation: transport of the intermediate, phosphatidic acid, from the plasma membrane to the endoplasmic reticulum for phosphatidylinositol resynthesis is not dependent on soluble lipid carriers or vesicular transport.

Authors:  J Whatmore; C Wiedemann; P Somerharju; P Swigart; S Cockcroft
Journal:  Biochem J       Date:  1999-07-15       Impact factor: 3.857

8.  Influence of alimentary zinc deficiency on the concentration of the second messengers D-myo-inositol-1,4,5-trisphosphate (IP3) and s,n-1,2-diacylglycerol (DAG) in testes and brain of force-fed rats.

Authors:  C Moser; H P Roth; M Kirchgessner
Journal:  Biol Trace Elem Res       Date:  1996-06       Impact factor: 3.738

9.  Identification of phospholipase B from Dictyostelium discoideum reveals a new lipase family present in mammals, flies and nematodes, but not yeast.

Authors:  Clive P Morgan; Robert Insall; Lee Haynes; Shamshad Cockcroft
Journal:  Biochem J       Date:  2004-09-01       Impact factor: 3.857

10.  Guanine-nucleotide- and adenine-nucleotide-dependent regulation of phospholipase D in electropermeabilized HL-60 granulocytes.

Authors:  M S Xie; G R Dubyak
Journal:  Biochem J       Date:  1991-08-15       Impact factor: 3.857
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