Does head-down tilt simulate zero gravity?

Six anesthetized female rhesus monkeys were studied to determine the effect of head-down tilt on renal function. Head-down tilt is believed to simulate zero gravity. Some animals were tilted from 0 degree to -5 degrees or -10 degrees and others from +10 degrees to -10 degrees. None of these maneuvers consistently altered renal function. These results are in accord with those reported in early literature for the human but contrary to more recent reports. The interpretation of the latter are seriously hampered by experimental design. If indeed zero gravity translocates blood to the thorax with a resultant diuresis and natriuresis, head-down tilt is not an appropriate model for weightlessness.