Literature DB >> 6477211

Pneumococcal meningitis. Late neurologic sequelae and features of prognostic impact.

V Bohr, O B Paulson, N Rasmussen.   

Abstract

We interviewed and neurologically reexamined 94 patients who had previous pneumococcal meningitis. The findings were allocated into groups with and without a causal relationship to the meningitis. The main sequelae after meningitis were dizziness (23%), tiredness (22%), mild memory deficits (21%), and gait ataxia (18%), whereas other focal neurologic signs were rare. By a rating (0 to 5) of the presence and severity of sequelae after meningitis, 54% of the patients were found to have sequelae. The clinical condition at the time of acute illness was studied in subgroups of patients who had different neurologic sequelae or high sequelae ratings. Gait ataxia was associated with a state of agitation and confusion when the patient was admitted for meningitis. High sequelae ratings on reexamination were associated with an affected consciousness at the acute stage of the disease and with high numbers of WBCs in the CSF at the time of hospitalization.

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Year:  1984        PMID: 6477211     DOI: 10.1001/archneur.1984.04050210043012

Source DB:  PubMed          Journal:  Arch Neurol        ISSN: 0003-9942


  19 in total

1.  Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis.

Authors:  Johann S Braun; Jack E Sublett; Dorette Freyer; Tim J Mitchell; John L Cleveland; Elaine I Tuomanen; Joerg R Weber
Journal:  J Clin Invest       Date:  2002-01       Impact factor: 14.808

Review 2.  Reprogramming the host response in bacterial meningitis: how best to improve outcome?

Authors:  M van der Flier; S P M Geelen; J L L Kimpen; I M Hoepelman; E I Tuomanen
Journal:  Clin Microbiol Rev       Date:  2003-07       Impact factor: 26.132

3.  Experimental pneumococcal meningitis: impaired clearance of bacteria from the blood due to increased apoptosis in the spleen in Bcl-2-deficient mice.

Authors:  Andreas Wellmer; Matthias von Mering; Annette Spreer; Ricarda Diem; Helmut Eiffert; Christiane Noeske; Stefanie Bunkowski; Ralf Gold; Roland Nau
Journal:  Infect Immun       Date:  2004-06       Impact factor: 3.441

4.  Pathophysiology and treatment of bacterial meningitis.

Authors:  Olaf Hoffman; R Joerg Weber
Journal:  Ther Adv Neurol Disord       Date:  2009-11       Impact factor: 6.570

5.  Streptococcus pneumoniae-induced inhibition of rat ependymal cilia is attenuated by antipneumolysin antibody.

Authors:  Robert A Hirst; Bashir J Mohammed; Timothy J Mitchell; Peter W Andrew; Christopher O'Callaghan
Journal:  Infect Immun       Date:  2004-11       Impact factor: 3.441

6.  Experimental pneumococcal meningitis causes central nervous system pathology without inducing the 72-kd heat shock protein.

Authors:  M G Täuber; S L Kennedy; J H Tureen; D H Lowenstein
Journal:  Am J Pathol       Date:  1992-07       Impact factor: 4.307

7.  Latex agglutination test: an adjunct to the laboratory diagnosis of pyogenic bacterial meningitis.

Authors:  B R Mirdha; U Gupta; R A Bhujwala
Journal:  Indian J Pediatr       Date:  1991 Jul-Aug       Impact factor: 1.967

Review 8.  Pathogenesis and pathophysiology of bacterial meningitis.

Authors:  A R Tunkel; W M Scheld
Journal:  Clin Microbiol Rev       Date:  1993-04       Impact factor: 26.132

9.  Clinical evaluation of pneumococcal meningitis in adults over a twelve-year period.

Authors:  G A Bruyn; H P Kremer; S de Marie; G W Padberg; J Hermans; R van Furth
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1989-08       Impact factor: 3.267

10.  Pneumococcal cell wall-induced meningitis impairs adult hippocampal neurogenesis.

Authors:  Olaf Hoffmann; Cordula Mahrhofer; Nina Rueter; Dorette Freyer; Bettina Bert; Heidrun Fink; Joerg R Weber
Journal:  Infect Immun       Date:  2007-06-25       Impact factor: 3.441

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