| Literature DB >> 6476965 |
Abstract
The inhibitory effect of amitriptyline and imipramine on human sperm motility was measured in vitro with a transmembrane migration method. The EC50 for amitriptyline and imipramine were 170 microM and 160 microM respectively. They were more potent than any other drug that had been tested on this pharmacological model. Transmembrane migration method was less sensitive than turbidimetric method to detect the sperm immobilizing effect of drugs.Entities:
Keywords: Contraception; Contraceptive Agents; Drugs--pharmacodynamics; Family Planning; Reproduction; Sperm Immobilizing Agents; Sperm Transport; Spermicidal Contraceptive Agents; Treatment
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Year: 1984 PMID： 6476965 DOI： 10.3109/01485018409161143
Source DB: PubMed Journal: Arch Androl ISSN： 0148-5016