Literature DB >> 647659

Induction by degraded carrageenan of colorectal tumors in rats.

K W Ashi, T Inagaki, Y Fujimoto, Y Fukuda.   

Abstract

Degraded carrageenan derived from the red seaweed Eucheuma spinosum was given to Sprague-Dawley rats through the diet, in drinking water or by stomach tube for up to 24 months. Carrageenan-induced squamous cell carcinomas, adenocarcinomas and adenomas in the colorectum were observed. Some rats had metastases to the regional lymph nodes of squamous cell carcinomas. These results show that degraded carrageenan is carcinogenic to the colorectum of the rat.

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Year:  1978        PMID： 647659     DOI： 10.1016/s0304-3835(78)94237-4

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  10 in total

1.  Algal toxins.

Authors:  M Collins
Journal:  Microbiol Rev       Date:  1978-12

Review 2.  Cancer in inflammatory bowel disease: lessons from animal models.

Authors:  Daniel A Sussman; Rebeca Santaolalla; Sebastian Strobel; Rishu Dheer; Maria T Abreu
Journal:  Curr Opin Gastroenterol       Date:  2012-07       Impact factor: 3.287

3.  Dietary factors in aetiology and prevention of cancer in man.

Authors:  A Kwiatkowski
Journal:  Environ Geochem Health       Date:  1990-09       Impact factor: 4.609

4.  Promotion of colorectal neoplasia in experimental murine ulcerative colitis.

Authors:  I Okayasu; T Ohkusa; K Kajiura; J Kanno; S Sakamoto
Journal:  Gut       Date:  1996-07       Impact factor: 23.059

5.  Histochemical study of colonic cancer in experimental colitis of rats.

Authors:  T Tamaru; H Kobayashi; S Kishimoto; G Kajiyama; F Shimamoto; W R Brown
Journal:  Dig Dis Sci       Date:  1993-03       Impact factor: 3.199

6.  The pre-ulcerative phase of carrageenan-induced colonic ulceration in the guinea-pig.

Authors:  S N Marcus; A J Marcus; R Marcus; S W Ewen; J Watt
Journal:  Int J Exp Pathol       Date:  1992-08       Impact factor: 1.925

7.  Occurrence of dysplasia and adenocarcinoma after experimental chronic ulcerative colitis in hamsters induced by dextran sulphate sodium.

Authors:  M Yamada; T Ohkusa; I Okayasu
Journal:  Gut       Date:  1992-11       Impact factor: 23.059

Review 8.  Animal models of colitis-associated carcinogenesis.

Authors:  Manasa Kanneganti; Mari Mino-Kenudson; Emiko Mizoguchi
Journal:  J Biomed Biotechnol       Date:  2011-01-12

Review 9.  Review of harmful gastrointestinal effects of carrageenan in animal experiments.

Authors:  J K Tobacman
Journal:  Environ Health Perspect       Date:  2001-10       Impact factor: 9.031

10.  A carcinogenic potency database of the standardized results of animal bioassays.

Authors:  L S Gold; C B Sawyer; R Magaw; G M Backman; M de Veciana; R Levinson; N K Hooper; W R Havender; L Bernstein; R Peto
Journal:  Environ Health Perspect       Date:  1984-12       Impact factor: 9.031
  10 in total

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