| Literature DB >> 6475669 |
G P Corbelli, L Stanzani, R Mastacchi, M Barbanti, L Montecchi.
Abstract
The activity of SAS 650, a new anti-inflammatory drug, on ex vivo and in vitro MDA production by platelets was compared to that of aspirin. The drug induced dose-dependent inhibition of in vitro MDA production by rat and guinea-pig platelets and also had good activity after 30 second of incubation in rat platelets, quicker than aspirin. SAS 650 preincubation reduced the in vitro inhibitory effect of ASA, as shown also by ex vivo experiments. The results of the present study support the involvement of SAS 650 in the platelet cyclooxygenase pathway.Entities:
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Year: 1984 PMID： 6475669 DOI： 10.1007/bf01978917
Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299