Literature DB >> 6474383

Effects of calcium channel blockade on histamine induced bronchoconstriction in mild asthma.

E H Walters, J Banks, A Fennerty, B H Davies.   

Abstract

Inhalation histamine dose-response curves were constructed 15 minutes after inhalation of saline placebo or verapamil (4 mg) for eight patients with mild atopic asthma in a double blind, random manner. No significant change in baseline specific airways conductance occurred after inhalation of verapamil, though there was a significant decrease in sensitivity to histamine (increase in threshold of response) (p less than 0.01). There was, however, an associated significant increase (p less than 0.01) in the slopes of the subsequent histamine dose-response curves.

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Year:  1984        PMID: 6474383      PMCID: PMC1020506          DOI: 10.1136/thx.39.8.572

Source DB:  PubMed          Journal:  Thorax        ISSN: 0040-6376            Impact factor:   9.139


  17 in total

1.  Airway response to carbachol in normal and asthmatic subjects: distinction between bronchial sensitivity and reactivity.

Authors:  J Orehek; P Gayrard; A P Smith; C Grimaud; J Charpin
Journal:  Am Rev Respir Dis       Date:  1977-06

2.  Calcium-channel blocking agents and asthma.

Authors:  E R McFadden
Journal:  Ann Intern Med       Date:  1981-08       Impact factor: 25.391

3.  Effect of nifedipine on bronchomotor tone and histamine reactivity in asthma.

Authors:  D O Williams; P J Barnes; H P Vickers; M Rudolf
Journal:  Br Med J (Clin Res Ed)       Date:  1981-08-01

Review 4.  Antiasthmatic drug therapy and calcium ions: review of pathogenesis and role of calcium.

Authors:  E Middleton
Journal:  J Pharm Sci       Date:  1980-02       Impact factor: 3.534

5.  Inhibition of exercise-induced asthma by a calcium antagonist, nifedipine.

Authors:  J Cerrina; A Denjean; G Alexandre; A Lockhart; P Duroux
Journal:  Am Rev Respir Dis       Date:  1981-02

6.  Bronchial responsiveness to inhaled histamine and exercise.

Authors:  R C Anderton; M T Cuff; P A Frith; D W Cockcroft; J L Morse; N L Jones; F E Hargreave
Journal:  J Allergy Clin Immunol       Date:  1979-05       Impact factor: 10.793

7.  Calcium antagonists in exercise-induced asthma.

Authors:  K R Patel
Journal:  Br Med J (Clin Res Ed)       Date:  1981-03-21

8.  The sources of calcium for acetylcholine-induced contractions of dog tracheal smooth muscle.

Authors:  J M Farley; P R Miles
Journal:  J Pharmacol Exp Ther       Date:  1978-11       Impact factor: 4.030

9.  Role of depolarization in acetylcholine-induced contractions of dog trachealis muscle.

Authors:  J M Farley; P R Miles
Journal:  J Pharmacol Exp Ther       Date:  1977-04       Impact factor: 4.030

10.  A new method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease.

Authors:  A B DUBOIS; S Y BOTELHO; J H COMROE
Journal:  J Clin Invest       Date:  1956-03       Impact factor: 14.808

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  3 in total

Review 1.  Calcium channel blockers and asthma.

Authors:  S Y So; M Ip; W K Lam
Journal:  Lung       Date:  1986       Impact factor: 2.584

Review 2.  Clinical studies with calcium antagonists in asthma.

Authors:  P J Barnes
Journal:  Br J Clin Pharmacol       Date:  1985       Impact factor: 4.335

3.  Nebulised sodium cromoglycate and verapamil in methacholine induced asthma.

Authors:  A L Boner; G Vallone; A Andreoli; R Biancotto; J O Warner
Journal:  Arch Dis Child       Date:  1987-03       Impact factor: 3.791

  3 in total

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