| Literature DB >> 6474001 |
O Lüderitz, K Tanamoto, C Galanos, G R McKenzie, H Brade, U Zähringer, E T Rietschel, S Kusumoto, T Shiba.
Abstract
Structural principles of the three regions of the lipopolysaccharide molecule are briefly discussed. One of the recently available, chemically synthesized lipid A analogues has been tested for biologic activities. The preparation was found to be toxic, pyrogenic, and mitogenic. The amounts, however, needed for expression of effects similar to those of lipid A were about 500 times higher. These investigations are aimed at verifying the proposed structure of lipid A and at evaluating structure-activity relationships.Entities:
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Year: 1984 PMID： 6474001 DOI： 10.1093/clinids/6.4.428
Source DB: PubMed Journal: Rev Infect Dis ISSN： 0162-0886