Literature DB >> 6472833

Antibiotic distribution in normal and osteomyelitic bone.

R H Fitzgerald.   

Abstract

Antibiotics are able to penetrate normal and osteomyelitic bone in a fashion that permits concentrations equivalent to those found in the serum following intravenous administration. There is no osseous barrier or gradient in osseous tissue to antibiotic penetration.

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Year:  1984        PMID： 6472833

Source DB:  PubMed          Journal:  Orthop Clin North Am        ISSN： 0030-5898            Impact factor:   2.472


  4 in total

1.  Biodegradable drug delivery system for the treatment of bone infection and repair.

Authors:  L Di Silvio; W Bonfield
Journal:  J Mater Sci Mater Med       Date:  1999 Oct-Nov       Impact factor: 3.896

2.  Continuous cefazolin infusion to treat bone and joint infections: clinical efficacy, feasibility, safety, and serum and bone concentrations.

Authors:  Valérie Zeller; Frédérick Durand; Marie-Dominique Kitzis; Luc Lhotellier; Jean-Marc Ziza; Patrick Mamoudy; Nicole Desplaces
Journal:  Antimicrob Agents Chemother       Date:  2008-12-15       Impact factor: 5.191

3.  Concentrations of ticarcillin and clavulanic acid in human bone after prophylactic administration of 5.2 g of timentin.

Authors:  D Adam; H D Heilmann; K Weismeier
Journal:  Antimicrob Agents Chemother       Date:  1987-06       Impact factor: 5.191

Review 4.  Bone as an effect compartment : models for uptake and release of drugs.

Authors:  David Stepensky; Lilach Kleinberg; Amnon Hoffman
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447
  4 in total

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