Literature DB >> 6471319

Death caused by recreational cocaine use. An update.

R E Mittleman, C V Wetli.   

Abstract

The epidemiologic, pathological, and toxicological findings of 60 cocaine-related overdose deaths from middle 1978 through 1982 were studied and compared with a previous publication by this office. In addition, 180 deaths where cocaine was an incidental toxicological finding are also discussed. Currently, the average street cocaine fatality victim is 29 years old, and 42% of the victims are female. Blacks comprise 39% of the cases. The blood cocaine concentration in "street cocaine" fatality victims averaged 6.2 mg/L with a wide range, necessitating careful interpretation of the toxicological results in conjunction with terminal events. Although autopsy findings were generally nonspecific, multiple needle-puncture marks with surrounding ecchymoses are typical of IV cocaine abuse. An increase in cocaine-related overdose deaths is anticipated because of its popularity, increasing availability, and, currently, the increased purity of street cocaine.

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Year:  1984        PMID: 6471319

Source DB:  PubMed          Journal:  JAMA        ISSN: 0098-7484            Impact factor:   56.272


  38 in total

1.  Block of a Ca(2+)-activated potassium channel by cocaine.

Authors:  L S Premkumar
Journal:  J Membr Biol       Date:  2005-04       Impact factor: 1.843

2.  Mechanisms of acute cocaine toxicity.

Authors:  Kennon Heard; Robert Palmer; Nancy R Zahniser
Journal:  Open Pharmacol J       Date:  2008

Review 3.  Clinical features, pathogenesis and management of drug-induced seizures.

Authors:  G Zaccara; G C Muscas; A Messori
Journal:  Drug Saf       Date:  1990 Mar-Apr       Impact factor: 5.606

Review 4.  Medical complications of intravenous drug use.

Authors:  M D Stein
Journal:  J Gen Intern Med       Date:  1990 May-Jun       Impact factor: 5.128

Review 5.  Respiratory toxicities from stimulant use.

Authors:  T E Albertson; W F Walby
Journal:  Clin Rev Allergy Immunol       Date:  1997       Impact factor: 8.667

6.  Pioglitazone attenuates acute cocaine toxicity in rat isolated heart: potential protection by metabolic modulation.

Authors:  Guy L Weinberg; Richard Ripper; Sarah Bern; Bocheng Lin; Lucas Edelman; Guido Digregorio; Mariann Piano; Douglas L Feinstein
Journal:  Anesthesiology       Date:  2011-06       Impact factor: 7.892

Review 7.  Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias.

Authors:  Michael E O'Leary; Jules C Hancox
Journal:  Br J Clin Pharmacol       Date:  2010-05       Impact factor: 4.335

8.  Drugs and homicide.

Authors:  D C McBride; C Burgman-Habermehl; J Alpert; D D Chitwood
Journal:  Bull N Y Acad Med       Date:  1986-06

Review 9.  Medical risks of cocaine use.

Authors:  C K Bates
Journal:  West J Med       Date:  1988-04

10.  Adaptive increase in D3 dopamine receptors in the brain reward circuits of human cocaine fatalities.

Authors:  J K Staley; D C Mash
Journal:  J Neurosci       Date:  1996-10-01       Impact factor: 6.167

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