| Literature DB >> 6471074 |
W Wierenga, B R Evans, G E Zurenko.
Abstract
An unusual acid-mediated rearrangement of o-nitrostyrene oxide afforded 1-(hydroxymethyl)-2,1-benzisoxazol-3(1H)-one which exhibited broad-spectrum antimicrobial and cytotoxic activity. A number of analogues were prepared by employing a modified zinc-reduction procedure on o-nitrobenzoate. Several of these analogues exhibited interesting antipseudomonal activity in agar and broth but were ineffective in vivo.Entities:
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Year: 1984 PMID： 6471074 DOI： 10.1021/jm00375a022
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446